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南方科技大学被确定为国家高等教育综合改革试验校。2012年4月,教育部同意建校,并赋予学校探索具有中国特色的现代大学制度、探索创新人才培养模式的重大使命。

南方科技大学对本科学生采用书院制管理模式,以书院、团委、社团等平台为载体,为学生营造了精彩的大学生活。

南方科技大学本科招生采用基于高考的综合评价录取模式,即高考成绩占60%,我校自主组织的能力测试成绩占30%(其中面谈成绩为5%),高中学业水平考试成绩占10%,按考生“631”综合成绩排名从高到低录取。综合评价录取模式由我校在2012年率先实施。

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首页 > 师资队伍 > 全部教师列表A-Z > 吴传跃

师资队伍

吴传跃


讲座教授

副校长

生物系

0755-88010011

第一科研楼238室

wucy@sustc.edu.cn

工作经历

吴传跃教授于1990年至1994年先后在美国匹兹堡大学生物系和Mayo Clinic 医学院S.C.Johnson医学研究中心接受博士后训练,1994年升为讲师(Instructor), 1996年至2000年担任美国阿拉巴马大学细胞生物学系助理教授(终身教职系列)。2000年被聘为美国匹兹堡大学医学院病理系副教授(终身教职), 2004年起担任美国匹兹堡大学医学院病理系教授(终身教职)。2009年被授予美国匹兹堡大学冠名讲席教授(Lombardi and Shinozuka Experimental Pathology Research Chair )。

吴传跃教授作为一个国际知名细胞生物学家, 在生物信息传导,细胞黏附,细胞外基质的形成和调控方面做了很多开创性工作,其研究成果是人类对于细胞黏附和细胞外基质形成机制了解的里程碑之一,开创了 一个由细胞表面受体控制细胞外基质形成学说。近年来的研究已证实这个学说对于各种细胞外基质形成和信息传导具有指导意义,对肿瘤细胞的黏附与转移有重要意 义。该系列研究成果在《细胞》、《细胞生物学杂志》,《分子细胞》,《自然结构生物学》等国际一流学术刊物上发表,对这一领域的研究产生了深远的影响。作 为在这一领域中具有国际影响的领军科学家,吴传跃教授多次应邀在重要国际学术会议(包括高登研究会议)上作大会报告或主持专题讨论,并被邀请在《细胞生物 学杂志》,《Current Opinion in Cell Biology》, 《Trends in Cell Biology》, 《EMBO Reports》等主要国际学术刊物发表综述文章以及担任多个国际学术杂志的编委和美国国立卫生研究院,美国癌症研究协会科学研究基金, 加拿大癌症研究协会科学研究基金, 英国Wellcome 基金等机构的评委和中国国家自然科学基金重点项目二审专家(医学科学部)。

 

学习经历

1985-1990  美国匹兹堡大学生物系  生物学博士学位

1982-1985  华东理工大学 生物化学专业  硕士学位

1978-1982  华东理工大学 生物化学专业 学士学位

 

所获荣誉

教育部长江学者讲座教授并入选“国家千人计划”人才

 

项目经费

细胞-细胞外基质黏附的分子基础及其调控机制,国家自然科学基金委面上项目,2015-1至2018-12,90万;
细胞-细胞外基质信号转导枢纽IPP复合物在肿瘤发生发展中的作用及其作为抗肿瘤靶体的研究,国家自然科学基金委重点项目,2015-1至2019-12,340.00万;
IPP复合物作为治疗肺癌新靶标的机制研究及相关抗肿瘤药物的研发,深圳市海外高层次人才创新创业专项资金项目,2014-12-19至2016-12-19,150万;
深圳细胞微环境重点实验室,重点实验室,2014-08-31至2016-08-31,300万。

 

代表文章

1.Wu, C., Friedman, R., and Chung, A.E.  Analysis of the assembly of laminin and the laminin-entactin complex with laminin chain-specific monoclonal and polyclonal antibodies.  Biochemistry (1988) 27:8780-8787.

2.Tsao, T., Hsieh, J.C., Durkin, M.E., Wu, C., Chakravarti, S., Dong, L.J., Lewis, M., and Chung, A.E.  Characterization of the basement membrane glycoprotein entactin synthesized in a baculovirus expression system.  J. Biol. Chem. (1990) 265:5188-5191.

3.Wu, C., Reing, J., and Chung, A.E.  Entactin forms a complex with fibronectin and co-localized in the extracellular matrix of the embryonal carcinoma-derived 4CQ cell line.  Biochem. Biophys. Res. Commun. (1991) 178(3):1219-1225.

4.Wu, C. and Chung, A.E.  Potential role of entactin in hemostasis:  specific interaction of entactin with fibrinogen A and B chains.  J. Biol. Chem. (1991) 266:18801-18807.

5.Mosher, D.F., Sottile, J., Wu, C., and McDonald, J.A.  Assembly of extracellular matrix.  Curr. Opin. Cell Biol. (1992) 4:810-818.

6.Chung, A.E., Dong, L.J., Wu, C., and Durkin, M.E.  Biological functions of entactin.  Kidney International (1993) 43:13-19.

7.Wu, C., Juliano, R.L., Bauer, J., and McDonald, J.A.  The 51 integrin fibronectin receptor, but not the 5 cytoplasmic domain, functions in an early and essential step in fibronectin matrix assembly.  J. Biol. Chem. (1993) 268:21883-21888.

8.Hsieh, J.-C., Wu, C., and Chung, A.E.  The binding of fibronectin to entactin is mediated through the 29 kDa amino terminal fragment of fibronectin and the G2 domain of entactin.  Biochem. Biophys. Res. Commun. (1994) 199(3):1509-1517.

9.Wu, C., Fields, A.J., Kapteijn, B.A.E., and McDonald, J.A.  The role of 41 integrin in cell motility and fibronectin matrix assembly.  J. Cell Sci. (1995) 108(2):821-829.

10.Wu, C., Chung, A.E., and McDonald, J.A.  A novel role for 31 integrin in extracellular matrix assembly.  J. Cell Sci. (1995) 108(6):2511-2523.

11.Wu, C., Keivens, V.M., O'Toole, T.E., McDonald, J.A., Ginsberg, M.H.  Integrin activation and cytoskeletal interaction are essential for the assembly of a fibronectin matrix.  Cell (1995) 83:715-724.

12.Hughes, P.E., Diaz-Gonzalez, F., Leong, L., Wu, C., McDonald, J.A., Shattil, S.J., Ginsberg, M.H.  Breaking the integrin hinge:  a defined structural constraint regulates integrin signaling.  J. Biol. Chem. (1996) 271:6571-6574.

13.Wu, C.  Integrin mediated fibronectin matrix assembly.  Trends in Glycoscience and Glycotechnology. (1996) 8(43):315-325.

14.Wu, C., Hughes, P.E., Ginsberg, M.H., and McDonald, J.A.  Identification of a new biological function for the integrin v3:  initiation of fibronectin matrix assembly.  Cell Adhesion and Communication (1996) 4:149 158.

15.Wu, C.  Roles of integrins in fibronectin matrix assembly.  Histology and Histopathology. (1997) 12:233-240

16.Li, F., J. Liu, R. Mayne, and Wu, C. Identification and characterization of a mouse protein kinase that is highly homologous to human integrin-linked kinase. Biochim. Biophys. Acta (1997) 1358:215-220

17.Wu, C., S. Y. Keightley, C. Leung-Hagesteijn, G. Radeva, M. Coppolino, S. Goicoechea, J. A. McDonald, and Dedhar, S.  Integrin-linked protein kinase regulates fibronectin matrix assembly, E-cadherin expression and tumorigenicity. J. Biol. Chem. (1998) 273: 528-536

18.Xie, W., Li, F., Kudlow, J. E. and Wu, C. Expression of the Integrin-linked kinase (ILK) in mouse skins: loss of expression in suprabasal layers of the epidermis and up-regulation by erbB-2. Am. J. Pathol. (1998) 153(2): 367-372

19.Tu, Y., Li, F. and Wu, C.  Nck-2, a novel Src homology2/3-containing adaptor protein that interacts with the LIM-only protein PINCH and components of growth factor receptor kinase-signaling pathways.  Mol. Biol. Cell (1998) 9: 3367-3382

20.Wu, C.  Integrin signaling in matrix assembly in “Signaling Through Cell Adhesion Molecules” (ed., J. Guan), CRC Press, (1999): 185-202

21.Tu, Y., Li, F., Goicoechea, S., and Wu, C.  The LIM-only protein PINCH directly interacts with the integrin-linked kinase (ILK) and is recruited to integrin-rich sites in spreading cells. Mol. Cell. Biol. (1999) 19(3): 2425-2434.

22.Huang, Y. and Wu, C. Integrin-linked kinase and associated proteins. Int. J. Mol. Med. (1999) 3: 563-572.

23.Li, F., Zhang, Y. and Wu, C.  Integrin-linked kinase is localized to cell-matrix focal adhesions but not cell-cell adhesion sites and the focal adhesion localization of integrin-linked kinase is regulated by the PINCH-binding ANK repeats. J. Cell Sci. (1999) 112: 4589-4599

24.Tu, Y. and Wu, C. Cloning, expression and characterization of a novel human Ras-related protein that is regulated by glucocorticoid hormone. Biochim. Biophys. Acta (1999) 1489: 452-456

25.Wu, C. Integrin-linked kinase and PINCH: partners in regulation of cell-extracellular matrix interaction and signal transduction. J. Cell Sci. (1999) 112: 4485-4489

26.Li, J., Mayne, R. and Wu, C. A novel muscle-specific 1 integrin binding protein (MIBP) that modulates myogenic differentiation. J. Cell Biol.  (1999) 147: 1391-1398

27.Wu, C.  Book Review: Guidebook to the Extracellular Matrix, Anchor, and Adhesion Proteins (Second Edition).  Trends Cell Biol. (2000) 10: 402

28.Huang, Y., Li, J., Zhang, Y. and Wu, C. The roles of integrin-linked kinase in the regulation of myogenic differentiation. J. Cell Biol.  (2000) 150: 861-872

29.Tu, Y., Liang, L., Frank, S.J. and Wu, C. Src homology 3 domain-dependent interaction of Nck-2 with insulin receptor substrate-1.  Biochem. J. (2001) 354 (2): 315–322

30. Velyvis, A., Yang, Y., Wu, C. and Qin, J. Solution structure of focal adhesion adaptor PINCH LIM1 domain and characterization of its interaction with integrin linked kinase ankyrin repeat domain. J. Biol. Chem. (2001) 276(7): 4932-4939

31.Tu, Y., Kucik, D.F. and Wu. C. Identification and kinetic analysis of the interaction between Nck-2 and DOCK180. FEBS Letters (2001) 491(3): 193-199

32.Tu, Y., Huang, Y., Zhang, Y., Hua, Y. and Wu, C. A new focal adhesion protein that interacts with integrin-linked kinase and regulates cell adhesion and spreading. J. Cell Biol.  (2001) 153: 585-598

33.Wu. C.  ILK interactions.  J. Cell Sci. (2001) 114:  2549-2550

34.Guo, L., Sanders, P.W., Woods, A and Wu, C.  The distribution and regulation of integrin-linked kinase in normal and diabetic kidneys. Am. J. Pathol. (2001) 159(5): 1735-1742

35.Wu, C. and Dedhar, S. Integrin linked kinase (ILK) and its interactors: a new paradigm for the coupling of extracellular matrix to actin cytoskeleton and signaling complexes. J. Cell Biol.  (2001) 155(4): 505-510

36.Zhang, Y., Guo, L., Chen, K. and Wu, C. A critical role of the PINCH-integrin-linked kinase interaction in the regulation of cell shape change and migration. J. Biol. Chem. (2002) 277(1): 318-326

37.Goicoechea, S.M., Yizeng, T., Hua, Y., Chen, K., Shen, T.-L., Guan, J.-L., and Wu, C. Nck-2 interacts with focal adhesion kinase and modulates cell motility.  Inter. J. Biochem. Cell Biol. (2002) 34(7): 791-805

38.Guo, L. and Wu, C.  Regulation of fibronectin matrix deposition and cell proliferation by the PINCH-ILK-CH-ILKBP complex.  FASEB Journal (2002) 16(10):1298-1300 (published online June 7, 2002 as 10.1096/fj.02-0089fje)

39.Kassis, J., Maeda, A., Teramoto, N., Takada, K., Wu, C., Klein, G., Wells, A. EBV-expressing AGS gastric carcinoma cell sublines present increased motility and invasiveness.  Inter. J. Cancer (2002) 99(5):644-651

40.Zhang, Y., Chen, K., Guo, L. and Wu, C. Characterization of PINCH-2, a new focal adhesion protein that regulates the PINCH-1-ILK interaction, cell spreading and migration. J. Biol. Chem. (2002) 277(41): 38328-38338

41.Zhang, Y., Chen, K., Tu, Y., Velyvis, A., Yang, Y., Qin, J. and Wu, C.  Assembly of the PINCH-ILK-CH-ILKBP complex precedes and is essential for localization of each component to cell-matrix adhesion sites.  J. Cell Sci. (2002) 115(24): 4777-4786

42.Fukuda, T., Guo, L., Shi, X. and Wu, C.  CH-ILKBP regulates cell survival by facilitating the membrane translocation of Protein kinase B/Akt. J. Cell Biol.  (2003) 160(7):1001-1008.

43.Tu, Y., Wu, S., Shi, X., Chen, K. and Wu, C.  Migfilin and Mig-2 link focal adhesions to filamin and the actin cytoskeleton and function in cell shape modulation. Cell (2003) 113(1): 37-47.

44.Velyvis, A., Vaynberg, J., Yang, Y., Vinogradova, O., Zhang, Y., Wu, C.* and Qin, J.* Structural and functional insights into PINCH LIM4 domain-mediated integrin signaling.  Nature Structural Biology (2003) 10(7): 558-564 (*Co-correspondence authors)

45.Li, J., Rao, H., Burkin, D., Kaufman, S.J. and Wu, C. The Muscle Integrin Binding Protein (MIBP) interacts with 71 integrin and regulates cell adhesion and laminin matrix deposition. Dev. Biol. (2003) 261(1): 209-219

46.Li, Y., Yang, J., Dai, C., Wu, C. and Liu, Y.  Role for integrin-linked kinase in mediating tubular epithelial to mesenchymal transition and renal interstitial fibrogenesis.  J. Clin. Invest. (2003) 112(4): 503-516

47.Attwell, S., Troussard, A., Mills, J., Wu, C. and Dedhar, S.  Integration of 1 integrin-mediated cell attachment, cytoskeletal localization and signaling by Integrin-Linked Kinase (ILK), CH-ILKBP, and the tumor suppressor PTEN.  Mol. Biol. Cell  (2003) 14(12): 4813-4825

48.Fukuda, T., Chen, K., Shi, X. and Wu, C.  PINCH-1 is an obligate partner of ILK functioning in cell shape modulation, motility and survival.  J. Biol. Chem. (2003) 278(51): 51324-51333

49.Kucik, D. F. and Wu, C.  Cell adhesion assays in “Cell Migration in Development” (ed., J. Guan), Humana Press, (2004): 43-54

50.Wu, C.  The PINCH-ILK-parvin complexes: assembly, functions and regulation. Biochim. Biophys. Acta (2004) 1692(2-3):55-62

51.Li, Z., Chen, X., Xie, Y., Shi, S., Feng, Z., Fu, B., Zhang, X., Cai, G., Wu, C, Wu, D., and Gu, Y.  Expression and Significance of Integrin-Linked Kinase in Cultured Cells, Normal Tissue, and Diseased Tissue of Aging Rat Kidneys.  J. Gerontol. (Series A-Biol. Sci. Med. Sci.) (2004) 59(10):984-996

52.Zhang, Y., Chen, K., Tu, Y., and Wu, C.  Distinct roles of two structurally closely related focal adhesion proteins, - and -parvins, in regulation of cell morphology and survival.      J. Biol. Chem. (2004) 279(40):41695-41705

53.Wu, C.  Migfilin and its binding partners: from cell biology to human diseases.  J. Cell Sci. (2005) 118: 659-664

54.Gkretsi, V., Zhang, Y., Tu, Y., Chen, K., Stolz, D.B., Yang, Y., Watkins, S.C. and Wu, C. Physical and functional association of migfilin with cell-cell adhesions. J. Cell Sci. (2005) 118: 697-710

55.Vaynberg, J., Fukuda, T., Chen, K., Vinogradova, O., Velyvis, A., Tu, Y., Ng, L., Wu, C.* and Qin, J.* Structure of an ultraweak protein-protein complex and its crucial role in regulation of cell morphology and motility.  Mol. Cell  (2005) 17: 513-523 (*Co-correspondence authors)

56.Qian, Y., Zhong, X., Flynn. D.C., Zheng, J.Z., Qiao, M., Wu, C., Dedhar, S., Shi, X., Jiang, B. H.  ILK mediates actin filament rearrangements and cell migration and invasion through PI3K/Akt/Rac1 signaling. Oncogene (2005) 24(19): 3154-3165

57.Yang, Y., Guo, L., Blattner, S. M., Mundel, P., Kretzler, M. and Wu, C.  The formation and phosphorylation of the PINCH-1-ILK--parvin complex are important for regulation of renal glomerular podocyte adhesion, architecture and survival. J. Am. Soc. Nephrol. (2005) 16(7):1966-76

58.Sepulveda, J. L., Gkretsi, V. and Wu, C. Assembly and signaling of adhesion complexes.  Curr. Top. Dev. Biol. (2005) 68: 183-225

59.Xu, Z., Fukuda, T., Li, Y., Zha, X., Qin, J. and Wu, C.  Molecular dissection of PINCH-1 reveals a mechanism of coupling and uncoupling of cell shape modulation and survival. J. Biol. Chem. (2005) 280(30): 27631-27637

60.Wu, C.  PINCH, N(i)ck and the ILK: network wiring at cell-matrix adhesions. Trends in Cell Biology (2005) 15(9):460-466

61.Chen, H., Huang, X. N., Chen, K., Guo, L., Tummalapali, L., Dedhar, S., St.-Arnaud, R., Wu, C., and Sepulveda, J. L. Role of the integrin-linked kinase/PINCH1/alpha-parvin complex in cardiac myocyte hypertrophy. Lab. Invest. (2005) 85(11):1342-56

62.Yaroslavskiy, B. B., Zhang, Y., Kalla, S. E., Palacios, V. G., Li, Y., Zaidi, M., Wu, C. and Blair, H. C.  NO-dependent Osteoclast Motility: Cytoskeletal Rearrangement by cGMP-dependent Protein Kinase I via VASP and Calcium-dependent Mechanisms. J. Cell Sci. (2005) 118(23):5479-87

63.Sepulveda, J. L. and Wu, C.  The Parvins. Cell. Mol. Life Sci. (2006) 63(1):25-35

64.Zhang, Y., Tu, Y., Gkretsi, V. and Wu, C.  Migfilin interacts with VASP and regulates VASP localization to cell-matrix adhesions and migration. J. Biol. Chem. (2006) 281(18):12397-407

65.Dai, C., Stolz, D. B., Bastacky, S. I. , St-Arnaud, R., Wu, C., Dedhar, S., Liu, Y. Essential role of integrin-linked kinase in podocyte biology: bridging the integrin and slit diaphragm signaling.  J. Am. Soc. Nephrol. (2006) 17(8):2164-75

66.Belvindrah, R., Nalbant, P., Ding, S., Wu, C., Bokoch, G. M., and Müller, U.  Integrin-linked kinase regulates Bergmann glia differentiation during cerebellar development.  Mol. Cell. Neurosci. (2006) 33(2):109-25

67.Chen, X., Li, Z., Feng, Z., Wang, J., Ouyang, C., Liu, W., Fu, B., Cai, G., Wu, C., Wei, R., Wu, D., Hong, Q. Integrin-linked kinase induces both senescence-associated alterations and extracellular fibronectin assembly in aging cardiac fibroblasts. J Gerontol A Biol Sci Med Sci  (2006) 61:1232-1245

68.Gozgit, J. M., Pentecost, B. T., Marconi, S. A., Otis, C. N. , Wu, C., Arcaro, K. F. Use of an aggressive MCF-7 cell line variant, TMX2-28, to study cell invasion in breast cancer. Mol Cancer Res. (2006) 4(12):905-13

69.Gkretsi, V., Bowen, W. C., Yang, Y., Wu, C., and Michalopoulos, G. K. Integrin-linked kinase is involved in matrix-induced hepatocyte differentiation.  Biochem. Biophys. Res. Commun. (2007) 353(3):638-43

70.Jung, K. Y., Chen, K., Kretzler, M. and Wu, C.  Transforming growth factor 1 (TGF-1) regulates the PINCH-1-ILK--parvin complex in glomerular cells. J. Am. Soc. Nephrol. (2007) 18(1):66-73

71.Gkretsi, V., Mars, W. M., Bowen, W. C., Barua, L., Yang, Y., Guo, L., St.-Arnaud, R., Dedhar, S., Wu, C., and Michalopoulos, G. K.  Loss of integrin linked kinase from mouse hepatocytes in vitro and in vivo results in apoptosis and hepatitis.  Hepatology (2007) 45(4):1025-34.

72.Wu, C.  Focal adhesion: a focal point in current cell biology and molecular medicine. Cell Adhesion & Migration (2007) 1(1):13-18

73.Ren, B., Yu, Y. P., Gavel, T., Tseng, G. C., Wu, C., Chen, K., Kokkinakis, D., Rao, U., Nelson, J., Michalopoulos, G. M. and Luo, J.-H. Analysis of Integrin α7 Mutations In Prostate Cancer, Liver Cancer, Glioblastoma Multiforme and Leiomyosarcoma.  J Natl Cancer Inst. (2007) 99(11):868-80

74.Wang, Y., Chang, J., Chen, K.-D., Li, S., Li, J. Y.-S., Wu, C. and Chien, S. Selective Adapter Recruitment and Differential Signaling Networks by VEGF vs. Shear Stress. Proc. Natl. Acad. Sci USA (2007) 104(21):8875-9

75.Papachristou, D. J., Gkretsi, V., Tu, Y., Shi, X., Chen, K., Larjava, H., Rao, U. N. M. and Wu, C.  Increased cytoplasmic level of migfilin is associated with higher grades of human leiomyosarcomas. Histopathology (2007) 51(4):499-508

76.Li, Y., Dai, C., Wu, C. and Liu, Y. PINCH-1 Promotes Tubular Epithelial-to-Mesenchymal Transition by Interacting with Integrin-Linked Kinase.  J. Am. Soc. Nephrol. (2007) 18(9):2534-43

77.Shi, X., Ma, Y-Q, Tu, Y., Chen, K., Wu, S., Fukuda, K., Qin, J., Plow, E. F. and Wu, C. The Mig-2/integrin interaction strengthens cell-matrix adhesion and modulates cell motility.  J. Biol. Chem. (2007) 282(28):20455-66

78.Kim, S. M., Kim, N., Lee, S., Kim, D. K., Lee, Y. M., Ahn, S. H., Song, J. H., Choi, B. K., Wu, C. and Jung, K. Y.  TGF-beta1-induced PINCH-1-ILK-alpha-parvin complex formation regulates mesangial cell proliferation and hypertrophy.  Exp. Mol. Med. (2007) 39(4):514-23

79.Zhang, W., Wu, Y., Wu, C. and Gunst, S. J.  Integrin-linked kinase (ILK) regulates N-WASp-mediated actin polymerization and tension development in tracheal smooth muscle. J. Biol. Chem. (2007) 282(47):34568-80

80.Samuelsson, A. R., Belvindrah, R., Wu, C., Müller, U. and Halfter, W.  β1-integrin signaling is essential for lens fiber survival.  Gene Reg. Sys. Biol. (2007) 1:177-189

81.Hu, K., Wu, C., Mars, W. M. and Liu, Y. tPA promotes myofibroblast activation through LRP-1-mediated recruitment of integrin signaling.  J. Clin. Invest. (2007) 117(12):3821-32

82.Chen, K., Tu, Y., Zhang, Y., Blair, H. C., Zhang, L. and Wu, C. PINCH-1 regulates the ERK-Bim pathway and contributes to apoptosis resistance in cancer cells.  J. Biol. Chem. (2008)  283(5):2508-2517

83.Wiebe, C. B., Petricca, G., Häkkinen, L., Jiang, G., Wu, C. and Larjava, H. S.,  Kindler Syndrome and periodontal disease: Review of the literature and 12-year follow-up of treatment outcome. J. Periodontology (2008) 79(5):961-966

84.Shi, X. and Wu, C.  A suppressive role of mitogen inducible gene-2 (Mig-2) in mesenchymal cancer cell invasion.  Mol Cancer Res. (2008) 6(5): 715 - 724

85.Ma, Y-Q., Qin, J., Wu, C. and Plow, E. F.  Kindlin-2 (Mig-2): A co-activator of beta3-integrins.  J. Cell Biol.  (2008) 181(3):439-46

86.Mayolo, A. A., Mays, L., Zhang, Y., Cheng, C.-M., Watkins, S. C., Wu, C. and LeDuc, P. R. Spatiotemporal response of living cell structures in Dictyostelium discoideum with semiconductor quantum dots. Nano Letters (2008) 8(5):1303-8      

87.Shi, X., Qu, H., Kretzler, M. and Wu, C.  The roles of PINCH-2 in regulation of glomerular cell shape change and fibronectin matrix deposition.  Am. J. Physiol. Renal Physiol. (2008) 295(1):F253-63

88.Wang, X., Fukuda, K., Byeon, I. J., Velyvis, A., Wu, C., Gronenborn, A. and Qin, J. The structure of -parvin CH2/paxillin LD1 complex reveals a novel modular recognition for focal adhesion assembly.  J. Biol. Chem. (2008) 283(30):21113-21119

89.Gkretsi, V., Apte, U., Mars, W. M., Bowen, W. C., Luo, J.-H., Yang, Y., Yu, Y. P., Orr, A., St.-Arnaud, R., Dedhar, S., Kaestner, K. H., Wu, C., and Michalopoulos, G. K.  Liver specific ablation of integrin linked kinase in mice results in abnormal histology, enhanced cell proliferation and hepatomegaly.  Hepatology (2008) 48(6):1932-41.

90.Qu, H. and Wu, C. Structural and signaling roles of PINCH in cell-matrix adhesion, migration and survival.  Cell Science (2008) 5(1): 232-248.

91.Papachristou, D. J., Gkretsi, V., Rao, U. N. M., Papachristou, G. I., Papaefthymiou, O. A., Wu, C.,  and Papavassiliou, A. G.  Expression of integrin-linked kinase and its binding partners in chondrosarcoma: association with prognostic significance.  Eur J Cancer (2008) 44(16):2518-25.

92.Larjava, H., Plow, E. F. and Wu, C.  Kindlins: Essential regulators of integrin signaling and cell-matrix adhesion.  EMBO Reports (2008) 9(12):1203-1208

93.Ithychanda, S. S., Das, M., Ma, Y., Ding, K., Wang, X., Gupta, S., Wu, C., Plow, E. F. and Qin, J.  Migfilin: a molecular switch in regulation of integrin activation. J. Biol. Chem. (2009) 284(7):4713-22

94.Akhtar, N., Marlow, R., Lambert, E., Schatzmann, F., Lowe, E., Cheung, J., Katz, E., Li, W., Wu, C., Dedhar, S., Naylor, M.J. and Streuli, C.H.  Molecular dissection of integrin signalling proteins in the control of mammary epithelial development and differentiation. Development (2009) 136(6):1019-27

95.Yang, Y., Wang, X., Hawkins, C. A., Chen, K., Vaynberg, J., Mao, X., Tu, Y., Zuo, X., Wang, J., Wang, Y. X., Wu, C., Tjandra, N. and Qin, J.  Structural basis of focal adhesion localization of LIM-only adaptor PINCH by integrin-linked kinase. J. Biol. Chem. (2009) 284(9):5836-5844

96.Zhang, Y., Tu, Y., Zhao, J., Chen, K. and Wu, C.  Reversion-Induced LIM (RIL) interaction with Src reveals a novel Src inactivation cycle. J. Cell Biol. (2009) 184(6):785-792. PMCID: 2699145

97.Petricca, G., Leppilampi, M., Jiang, G., Owen, G. R., Wiebe, C., Koivisto, L., Hakkinen, L., Wu, C. and Larjava, H.  Localization and potential function of kindlin-1 in periodontal tissues.  Eur. J. Oral. Sci. (2009) 117(5):518-27

98.Yue, W., Sun, Q., Landreneau, R., Wu, C., Yu, J. and Zhang, L. Fibulin-5 suppresses lung cancer invasion by inhibiting matrix metalloproteinase-7 expression.  Cancer Research (2009) 69(15):6339-6346

99.Apte, U., Gkretsi, V., Bowen, W. C., Mars, W. M., Luo, J. H., Donthamsetty, S., Orr, A., Monga, S. P., Wu, C. and Michalopoulos, G. K. Enhanced liver regeneration following changes induced by hepatocyte-specific genetic ablation of integrin-linked kinase. Hepatology (2009) 50(3):844-851. PMCID: PMC2914599

100.Liang, X. Sun, Y.F., Yi, M. Q., Powell, H., Rearden, A., Wu, C., Evans, S. E. and Chen, J. Targeted ablation of PINCH1 and PINCH2 from murine myocardium results in dilated cardiomyopathy and early postnatal lethality.  Circulation (2009) 120(7):568-576

101.Yuan, Y., Nymoen, D. A., Dong, H. P., Stavnes, H. T., Rossnes, A. K., Bjørang, O., Wu, C., Nesland, J. M., Davidson, B., Tenascin-X is a novel diagnostic marker of malignant mesothelioma. Am. J. Surg. Pathol. (2009) 33(11):1673-82

102.Zhao, J., Zhang, Y., Ithychanda, S. S., Tu, Y., Chen, K., Qin, J. and Wu, C.  Migfilin interacts with Src and contributes to cell-matrix adhesion- mediated survival signaling.  J. Biol. Chem. (2009) 284(49):34308-20. PMCID: PMC2797199

103.Shao, H., Wu, C., and Wells, A. Phosphorylation of -actinin-4 upon epidermal growth factor (EGF) exposure regulates its interaction with actin.  J. Biol. Chem. (2009) 285(4):2591-600. PMCID: PMC2807316

104.Fukuda, K., Gupta, S. Chen, K., Wu, C. and Qin, J. The pseudo-active site of ILK is essential for its binding to -parvin and localization to focal adhesions. Mol. Cell (2009) 36(5):819-830. PMCID: PMC2796127

105.Donthamsetty, S., Bowen, W., Mars, W., Bhave, B., Luo, J. H., Wu, C., Hurd, J., Orr, A., Bell, A., and Michalopoulos G. M., Liver Specific Ablation of Integrin Linked Kinase (ILK) in Mice Results in Enhanced and Prolonged Cell Proliferation and Hepatomegaly after Phenobarbital Administration. Toxicol. Sci. (2010) 113(2):358-66. PMCID: PMC2807039

106.Owen, G. R., Häkkinen, L., Wu, C., and Larjava, H. A reproducible technique for specific labeling of antigens using preformed fluorescent molecular IgG-F(ab’)2 complexes from primary antibodies of the same species. Microsc. Res. Tech. (2010) 73(6):623-30. PMCID: PMC3225404

107.Kang, Y. S., Li, Y., Dai, D., Kiss, L.P., Wu, C. and Liu, Y. Inhibition of integrin-linked kinase blocks podocyte epithelial-mesenchymal transition and ameliorates proteinuria.  Kidney International (2010) 78(4):363-73.  PMCID: PMC3065782

108.Han, Y.-C., Yu, Y. P., Nelson, J., Wu, C., Michalopoulos, G. K. and Luo, J.-H. Interaction of integrin linked kinase (ILK) and MCM7 mediating integrin 7 induced cell growth suppression. Cancer Research (2010) 70(11):4375-84.

109.Perera, P. M. , Wypasek, E., Madhavan, S., Rath-Deschner, B., Liu, J., Nam, J., Rath, B., Huang, Y., Deschner, J., Piesco, N., Wu, C., Agarwal, S.  Mechanical signals control Sox-9, Vegf and c-Myc expression and cell proliferation during inflammation via Integrin-linked kinase, B-Raf, and ERK 1/2-dependent signaling in articular chondrocytes.  Arthritis Research & Therapy (2010) 12(3):R106. PMCID: PMC2911896

110.Bledzka, K., Bialkowska, K., Nie, H., Qin, J., Byzova, T., Wu, C., Plow, E. F. and Ma, Y.-Q.  Tyrosine phosphorylation of 3 integrin regulates kindlin-2 binding and integrin activation. J. Biol. Chem. (2010) 285(40):30370-4. PMCID: PMC2945529

111.Yuan, Y., Dong, H. P., Nymoen, D. A., Nesland, J. M., Wu, C., and Davidson, B. PINCH-2 expression in cancers involving the serosal cavities. Cytopathology (2011) 22(1):22-9.  PMCID: PMC3225403

112.Donthamsetty, S., Bhave, V. S., Kliment, C. S., Bowen, W. C., Mars, W. M., Bell, A. W., Stewart, R. E., Orr, A., Wu, C., and Michalopoulos, G. M. Excessive hepatomegaly of mice with hepatocyte-targeted elimination of integrin linked kinase following treatment with 1,4-bis [2-(3,5-dichaloropyridyloxy)] benzene.  Hepatology (2011) 53(2):587-95

113.Qu, H., Tu, Y., Shi, X., Larjava, H., Saleem, M. A., Shattil, S. J., Fukuda, K., Qin, J., Kretzler, M., and Wu, C. Kindlin-2 regulates podocyte adhesion and fibronectin matrix deposition through interactions with phosphoinositides and integrins. J. Cell Sci. (2011) 124:879-91. PMCID: PMC3048888

        Featured in the April 2011 issue of the North American Vascular Biology Organization (NAVBO) Vascular Biology Publications Alert

114.Wang, D., Li, Y., Wu, C. and Liu, Y.  PINCH1 is transcriptional regulator in podocytes that interacts with WT1 and represses podocalyxin expression.  PLoS ONE (2011) 6(2):e17048. PMCID: PMC3044754

115.Liu, Z., Blattner, S. M., Tu, Y., Tisherman, R., Wang, J. H., Rastaldi, M. P., Kretzler, M., Wu, C.  -actinin-4 and CLP36 deficiencies contribute to podocyte defects in multiple human glomerulopathies.  J. Biol. Chem. (2011) 286(35):30795-805.  PMCID: PMC3162440

116.Liu, J., Fukuda, K., Xu, Z., Ma, Y.-Q., Hirbawi, J., Mao, X., Wu, C., Plow, E. F., Qin, J.  Structural basis of phosphoinositide binding to Kindlin-2 pleckstrin homology domain in regulating integrin activation.  J. Biol. Chem. (2011)  286(50):43334-42.  PMCID: PMC3234820

117.Bavagnoli, L., Dundon, W.G., Garbelli, A., Zecchin, B., Milanib, A., Parakkal, G., Baldanti, F., Paolucci, S., Volmer, R., Tu, Y., Wu, C., Capua, I., and Maga, G.  The PDZ-ligand and SRC-homology type 3 domains of epidemic avian influenza virus NS1 protein modulate human SRC kinase activity during viral infection.  PLoS ONE (2011), 6(11):e27789. Epub 2011 Nov 14. PMCID: PMC3215730

118.Donthamsetty, S., Mars, W. M., Orr, A., Wu, C., and Michalopoulos, G. M. Protection against Fas-induced fulminant hepatic failure in liver specific integrin linked kinase knockout mice.  Comparative Hepatology 2011, 10:11 doi:10.1186/1476-5926-10-11

119.He, H., Ding, F., Li, Y,, Chen, H., Luo, A., Wu, C., and Liu, Z.  Migfilin regulates esophageal cancer cell motility through promoting GSK-3β mediated degradation of β-catenin. Mol Cancer Res (2012) 10(3):273-81

120.Lin, L., Wu, C., and Hu, K.  tPA activates NF-κB signaling through annexin A2 and Mac-1-mediated integrin-linked kinase pathway. J. Am. Soc. Nephrol. (2012) 23(8):1329-38. PMCID: PMC3402285

121.Xiao, G., Cheng, H., Cao, H., Chen, K., Tu, Y., Yu, S., Jiao, H., Yang, S., Im, H.-J., Chen, D., Chen, J., and Wu, C.  Critical Role of Filamin-binding LIM Protein 1 (FBLP-1)/Migfilin in Regulation of Bone Remodeling.  J. Biol. Chem. (2012) 287(25):21450-60. PMCID: PMC3375566

122.Qin, J. and Wu, C. ILK: a pseudokinase in the center stage of cell-matrix adhesion and signaling.  Current Opinion in Cell Biology (2012) 24(5):607-13. PMCID: PMC3467332

123.Ou, Y. , Ma, Li, Dong, L., Ma, L., Zhao, Z.,  Ma, Li, Zhou, W., Fan, J.,  Wu, C., Yu, C., Zhan Q., and Song, Y. Migfilin promotes migration and invasion in human glioma through EGFR-mediated PLC-γ and STAT3 signaling pathways. J. Biol. Chem. (2012) 287(39):32394-405. PMCID: PMC3463316

124.Fan, J., Ou, Y.,   Wu, C., Yu, C., Song, Y., and Zhan, Q. Migfilin sensitizes cisplatin-induced apoptosis in human glioma cells in vitro. Acta Pharmacol Sin. 2012 Oct;33(10):1301-10.  PMID: 22983390

125.Davidson B, Holth A, Nguyen MT, Tropé CG and Wu C. Migfilin, α-parvin and β-parvin are differentially expressed in ovarian serous carcinoma effusions, primary tumors and solid metastases.  Gynecol Oncol. 2013. 128(2):364-70. PMC3552080

126.Gkretsi, V.,  Papanikolaou, V., Dubos, S., Papathanasiou, I.,  Giotopoulou, N., Valiakou, V., Wu, C., Malizos, K. N., and Tsezou, A., Migfilin’s elimination from osteoarthritic chondrocytes further promotes the osteoarthritic phenotype via beta-catenin upregulation. Biochem. Biophys. Res. Commun. 2013, 430(2):494-9. PMC3764434

127.Gkretsi, V., Papanikolaou, V., Zacharia, LC., Athanassiou, E., Wu, C. and Tsezou, A. Mitogen-inducible gene-2 (Mig-2) and Migfilin expression is reduced in human breast cancer samples.  Anticancer Res.  2013, 33(5):1977-81.

128.Song, C., Zhu, S., Wu*, C. and Kang*, J. Histone deacetylase (HDAC) 10 suppresses cervical cancer metastasis through inhibition of matrix metalloproteinase (MMP) 2 and 9 expression.  J. Biol. Chem.  2013 Sep 27;288(39):28021-33 (*co-correspondence authors). PMC3784715

129.Teräväinen1,T. P., Myllymäki1, S. M., Friedrichs, J.,  Strohmeyer, N., Moyano, J.V., Wu, C., Matlin, K. S., Muller, D. J.,  and Manninen, A.  αV-integrins are required for mechanotransduction in MDCK epithelial cells.  PLoS One  2013 Aug 19;8(8):e71485. PMC3747215

130.Donthamsetty, S., Bhave, V.S., Mars, W.M., Bowen, W.C., Orr, A., Haynes, M, M., Wu, C., Michalopoulos, G.K. Role of PINCH and Its Partner Tumor Suppressor Rsu-1 in Regulating Liver Size and Tumorigenesis.  PLoS One  2013 Sep 18;8(9):e74625. PMC3776730

131.Cui X, Zhao Z, Liu D, Guo T, Li S, Hu J, Liu C, Yang L, Cao Y, Jiang J, Liang W, Liu W, Li S, Wang L, Wang L, Gu W, Wu C, Chen Y, Li F.  Inactivation of miR-34a by aberrant CpG methylation in Kazakh patients with esophageal carcinoma. J Exp Clin Cancer Res. 2014 Feb 17;33(1):20. [Epub ahead of print]

132.Fluorescence resonance energy transfer detection methods: Sensitized emission and acceptor bleaching. Qian J, Yao B, Wu C. Exp Ther Med. 2014 Nov;8(5):1375-1380

133.Qu H, Tu Y, Guan JL, Xiao G, Wu C. Kindlin-2 tyrosine phosphorylation and interaction with Src serve as a regulatable switch in the integrin outside-in signaling circuit.  J Biol Chem. 2014 Nov 7;289(45):31001-13.

134.Zhu K, Yi J, Xiao Y, Lai Y, Song P, Zheng W, Jiao H, Fan J, Wu C, Chen D, Zhou J, Xiao G. Impaired bone homeostasis in amyotrophic lateral sclerosis mice with muscle atrophy. J Biol Chem. 2015 Mar 27;290(13):8081-94.

135.Liu Z, Zhan Y, Tu Y, Chen K, Liu Z, Wu C. PDZ and LIM domain protein 1(PDLIM1)/CLP36 promotes breast cancer cell migration, invasion and metastasis through interaction with α-actinin. Oncogene. 2015 Mar 5;34(10):1300-11.

136.Chuanyue Wu*, Hongli Jiao, Yumei Lai, Wei Zheng, Ka Chen, Weimin Deng, Pingping Song, Ke Zhu, Huiling Cao, Deborah L. Galson, Jie Fan, Hee-Jeong Im, Yujie Liu, Ju Chen, Di Chen, Guozhi Xiao*. Kindlin-2 Controls TGF-β Signaling and Sox9 Expression to Regulate Chondrogenesis. Nature Communication. Accepted.

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