南方科技大学是由中国广东省领导和管理、深圳市举全市之力创建的一所公办创新型大学,目标是迅速建成国际化高水平研究型大学,建成中国重大科学技术研究与拔尖创新人才培养的重要基地……

南方科技大学以学分制、导师制、书院制为基础,以人才培养的个性化、小班化、国际化为特色,通过为一流的人才培养体系,培养人格健全、基础扎实、能力突出、具有国际视野、社会责任感、创新精神和实践能力的高素质人才。

南方科技大学被确定为国家高等教育综合改革试验校。2012年4月,教育部同意建校,并赋予学校探索具有中国特色的现代大学制度、探索创新人才培养模式的重大使命。

南方科技大学对本科学生采用书院制管理模式,以书院、团委、社团等平台为载体,为学生营造了精彩的大学生活。

南方科技大学本科招生采用基于高考的综合评价录取模式,即高考成绩占60%,我校自主组织的能力测试成绩占30%(其中面谈成绩为5%),高中学业水平考试成绩占10%,按考生“631”综合成绩排名从高到低录取。综合评价录取模式由我校在2012年率先实施。

南科大教育基金会由理事会、监事会、秘书处组成。理事会是基金会的最高权力机构;监事会负责检查财务和会计资料,监督理事会遵守法律和章程的情况;秘书处是基金会常设办事机构,在理事会领导下负责基金会的日常工作。

学校党委切实履行党建工作职责,不断强化班子建设和基层党组织建设,充分发挥好党委对学校各项工作的核心统领作用和各党支部的战斗堡垒作用,切实开展组织统战和党风廉政建设各项工作。学校高度重视群团组织建设,充分调动全体师生员工积极性,维护教职工的合法权益,推进学校民主管理,促进学校健康发展,全力营造齐心协力、团结向上、奋发有为的干事创业氛围。

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首页 > 师资队伍 > 全部教师列表A-Z > Dinshaw J Patel

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Dinshaw J Patel


讲座教授

生物系

0755-88018446

pateld@mskcc.org

个人简介:
Dinshaw J. Patel教授,1968年于美国纽约大学获得化学博士学位,同时在纽约大学医学院完成了一年的博士后研究,接着在美国电话电报公司(AT&T)贝尔实验室继续从事了两年的博士后工作。在美国电话电报公司获得了永久职位后开始了长达15年用核磁共振技术探索环肽,蛋白质和核酸结构的研究。2004年获得美国哥伦比亚大学终身教授职位,在之后的8年里一直从事用核磁共振技术探索核酸与靶向核酸药物的结构生物学研究。1992年被美国纪念斯隆-凯特琳癌症医院招募为教授,并着手建立结构生物学平台。从2000年开始转型用X射线衍射晶体学技术,结合其他生物化学和生物物理学手段来探寻生物体内有重要调控功能,与疾病密切相关的生物大分子的结构和功能。
现为美国科学院院士,美国人文与科学院院士,美国纪念斯隆-凯特琳癌症医院教授,是RNA干扰和表观遗传学领域的国际知名结构生物学专家,发表过500余篇论文和综述,从其2003年至今的论文摘录里,每年都有大量的文章发表在Nature、 Science、 Cell等国际权威学术期刊上。于2015年11月引进为深圳市南方科技大学生物系讲座教授。


工作经历:
1967            美国纽约大学医学院                        生物化学博士后
1968-1969       美国电话电报公司贝尔实验室                生物物理博士后
1970-1984       美国电话电报公司贝尔实验室                     工程师
1984-1992       美国哥伦比亚大学                               教授
1992-至今       美国纪念斯隆-凯特琳癌症医院                    教授
1994-至今       美国康奈尔大学医学院                           教授
2015-至今       中国科学院爱因斯坦讲席教授计划                 讲席教授
2015-至今       深圳南方科技大学                              讲座教授

 

学习经历:
1961            印度孟买大学                                化学学士学位   
1963            美国加州理工大学                            化学硕士学位          
1968            美国纽约大学                                化学博士学位


所获荣誉:
1961-1963      Jamshetjee N.Tata 学者
1983           美国电话电报公司贝尔实验室杰出工程师奖
1992           Abby Rockefeller Mauzé主任
1997           纽约大学杰出校友奖
1997-1999   (97-98)哈维机构副主席,(98-99)哈维机构主席
2013         美国国立卫生院院长革命创新性R01奖
2009         美国科学院院士
2014         美国人文与科学院院士


代表文章: (近五年内)
1.Du, J., Johnson, L. M., Jacobsen, S. E. and Patel, D. J. (2015). DNA methylation pathways and their crosstalk with histone methylation. Nat. Rev. Mol. Cell Biol. 16, 519-532.
2.Noh, K. M., Wang, H., Kim, H. R., Wenderski, W., Fang, F., Li, C., Dewell, S., Ferris, A., Hughes, S. H., Zheng, D., Melnick, A, Patel, D. J., Li, H. and Allis, C. D. (2015). Engineering of a histone recognition domain in Dnmt3a alters the epigenetic landscape and phenotypic features of mouse ESCs. Mol. Cell 59, 89-103.
3.Webster, A., Li, S., Hur, J. K., Wachsmuth, M., Bois, J., Perkins, E. M., Patel, D. J. and Aravin, A. A. (2015). Aub and Ago3 are recruited to nuage through two mechanisms to form a ping-pong complex assembled by Krimper. Mol. Cell 59, 564-575.
4.Chen, S., Ze, Y., Wilkinson, A., Deshpande, A. J., Sidoli, S., Krajewski, K., Strahl, B. D., Garcia, B. A., Armstrong, S. A., Patel, D. J. and Gozani, O. (2015). The PZP domain of AF10 senses unmodified H3K27 to regulate DOT1L-methylation at H3K79. Mol. Cell 60, 319-327.
5.Huang, H., Stromme, C. B., Saredi, G., Hodl, M., Strandsby, A., Strandsby, A., Gonzalez-Aguilera, C., Chen, S., Groth, A. and Patel, D. J. (2015). A unique binding mode enables MCM2 to chaperone histones H3-H4 at replication forks. Nat. Struct. Mol. Biol. 22, 618-626.
6.Dai, Q., Ren, A., Westholm J. O., Patel, D. J. and Lai, E. (2015). Common and distinct DNA-binding and regulatory activities of the BEN-solo transcription factor family. Genes Dev.29, 48-62.
7.Chen, S., Ruflange, A., Huang, H., Nourani, A. and Patel, D. J. (2015). Structural basis of histone H3/H4 tetramer maintenance during transcription by chaperone Spt2. Genes Dev.29, 1326-1340.
8.Murn, J., Zarnack, K., Yang, Y. J., Durak, O., Murphy, E. A., Cheloufi, S., Gonzalez, D. M., Teplova, M., Curk, T., Zuber, J., Patel D. J., Ule, J., Luscombe, N. M., Tsai, L. H., Walsh, C. A. and Shi, Y. (2015). Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt. Genes Dev. 29, 501-512.
9.Ren, A., Wang, X. C., Kellenberger, C. A., Rajashankar, K. R., Jones, R., Hammond, M. C. and Patel, D. J. (2015). Structural basis for molecular discrimination by a 3’,3’-cGAMP riboswitch. Cell Reports 11, 1-12.
10.Ren, A., Xue, Y., Peselis, A., Serganov, A., Al-Hashimi, H. and Patel, D. J. (2015). Structuraland Dynamic Basis for Low-Affinity, High-Selectivity Binding of L-Glutamine by the Glutamine Riboswitch. Cell Reports 13, 1800-1813.
11.Vasilyev, N., Polonskaia, A., Darnell, J. C., Darnell, R. B., Patel, D. J. and Serganov, A. (2015). Crystal structure reveals specific recognition of a G-quadruplex RNA by a β-turn in the RGG motif of FMRP. Proc. Natl. Acad. Scis. USA. 112, E5391-E5400.
12.Kosutic, M., Neuner, S., Ren, A., Flur, S., Wunderlich, C., Mayrhofer, E., Vusurovic, N., Seikowski, J., Westhof, E., Hobartner, C., Patel, D. J., Kreitz, C. and Micure, R. (2015). A Mini-Twister Variant and Impact of Residues/Cations on the Phosphodiester Cleavage of this Ribozyme Class. Angew. Chemie Int. Edn. 54, 15128-15133.
13.Malinina, L., Simanshu, D. K., Zhai, X., Samygina, V. R., Kamlekar, R., Kenoth, R., Ochoa-Lizarralde, B., Molotkovsky, J. G., Patel, D. J. and Brown, R. E. (2015). Sphingolipid transfer proteins defined by the GLTP-fold. Quart. Rev. Biophys. 48, 281-322.
14.Johnson, L. M., Du, J., Hale, C. J., Bischof, S., Feng, S., Chodavarapu, R. K., Zhong, X., Marson, G., Pellergrini, M., Segal, D. J., Patel, D. J. and Jacobsen, S. E. (2014). SRA- and SET-domain-containing proteins link RNA polymerase V occupancy to DNA methylation.Nature 507, 124-128.
15.Swarts, D. C., Jore, M. M., Westra, E. R., Zhu, Y., Janssen, J. H., Snijders, A. P., Wang, Y., Patel, D. J., Berenguer, J., Brouns, S. J. and van der Oost, J. (2014). DNA-guided DNA interference by prokaryotic Argonaute. Nature 507, 258-261.
16.Zhong, X., Du, J., Hale, C. J., Gallego-Bartolome, J., Feng, S., Vashisht, A. A., Chory, J., Wohlschlegel, J. A., Patel, D. J. and Jacobsen, S. E. (2014). Molecular mechanism of action of plant DRM de novo DNA methyltransferases. Cell 157, 1050-1060.
17.Lim, J., Ha, M., Chang, H., Kwon, S. C., Simanshu, D. K., Patel, D. J. and Kim, V. N. (2015). Uridylation by TUT4 and TUT7 marks mRNA for degradation. Cell 159, 1365-1376.
18.Stroud, H., Do, T., Du, J., Zhong, X., Feng, S., Johnson, L., Patel, D. J. and Jacobsen, S. E. (2014). Non-CG methylation patterns shape the epigenetic landscape in Arabidopsis. Nat. Struct. Mol. Biol. 21, 64-72.
19.Swarts, D. C., Makarova, K., Wang, Y., Nakanishi, K., Ketting, R. F., Koonin, E. V., Patel, D. J. and van der Oost, J. (2014). The evolutionary journey of Argonaute proteins. Nat. Struct. Mol. Biol. 21, 743-753.
20.Tian, Y., Simanshu, D. K., Ma, J. B., Park, J-E, Heo, I., Kim, V. N. & Patel, D. J. (2014). A phosphate-binding pocket within the platform-PAZ-connector helix cassette of human Dicer. Mol. Cell 53, 606-616.
21.Du, J., Johnson, L. M., Groth, M., Feng, S., Hale, C. J., Li, S., Vashisht, A. A., Gallego-Bartolome, J., Wohlschlegel, J. A., Patel, D. J. and Jacobsen, S. E. (2014). Mechanism of DNA methylation-directed histone methylation by KRYPTONITE. Mol. Cell 55, 495-504.
22.Lee, M., Choi, Y., Kim, K., Jin, H., Lim, J., Nguyen, T. A., Yang, J., Jeong, M., Giraldez, A. J., Yang, H., Patel, D. J. and Kim, V. N. (2015). Adenylation of maternally inherited microRNAs by Wispy. Mol Cell 56, 696-707.
23.Ren, A. and Patel, D. J. (2014). c-di-AMP binds the ydaO riboswitch in two pseudo-symmetry-related pockets. Nat. Chem. Biol. 10, 780-786.
24.Ren, A., Kosutic, M., Rajashankar, K. R., Frener, M., Santner, T., Westhof, E., Micura, R. and Patel, D. J. (2014). In-line alignment and Mg2+ coordination at the cleavage site of the twister ribozyme. Nat. Commun.15: 5534.
25.Oh, Y-S., Gao, P., Lee, K., Ceglia, I., Zhang, X., Ahn, J-H., Chait, B. T., Patel, D. J., Kim, Y. & Greengard, P. (2013). SMARCA3, a chromatin-remodeling factor, is required for p11-dependent antidepressant action. Cell 152, 831-843.
26.Shen, J., Xia, Y., Khotskaya, Y. B., Huo, L., Nakanishi, K., Lim, S-O., Du, Y., Wang, Y., Chang, W-C., Chen, C-H., Hsu, J. L., Lam, Y. C., James, B. P., Liu, C-G., Liu, X., Patel, D. J. & Hung, M. C. (2013). EGFR modulates miRNA maturation in response to hypoxia through phosphorylation of Ago2. Nature 497, 383-387.
27.Law, J. A., Du, J., Hale, C. J., Feng, S., Krajewski, K., Strahl, B. D., Patel, D. J. & Jacobsen, S. E. (2013). Polymerase IV occupancy at RNA-directed DNA methylation sites requires SHH1. Nature 498, 385-389.
28.Sun, X-J., Wang, Z., Wang, L., Jiang, Y., Chen, W-Y., Melnick, A., Patel, D. J., Nimer, S. D. & Roeder, R. G. (2013). A stable transcription factor complex nucleated by oligomeric AML1-ETO controls leukaemogenesis. Nature 500, 93-97.
29.Simanshu, D. K., Kamlekar, R. K., Wijesinghe, D. S., Zou, X., Zhai, X., Mishra, S. K., Molotkovsky, J. G., Malinina, L., Hincliffe, E. H., Chalfant, C. E., Brown, R. E. & Patel, D. J. (2013). Non-vesicular trafficking by a ceramide-1-phosphate transfer protein regulates eicosanoids. Nature 500, 463-467.
30.Gao, P., Ascano, M., Wu, Y., Barchet, W., Gaffney, B. L., Zillinger, T., Serganov, A., Jones, R. A., Hartmann, G., Tuschl, T. and Patel, D. J. (2013). Cyclic [G(2’,5’)pA(3’,5’)p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase. Cell 153, 1094-1107.
31.Gao, P., Ascano, M., Zillinger, T., Wang, Y., Dai, P., Serganov, A. A., Gaffney, B. L., Shuman, S., Jones, R., Deng, L., Hartmann, G., Barchet, W., Tuschl, T. and Patel, D.J. (2013). Structure-function analysis of STING activation by c[G(2’,5’)pA(3’,5’)p] and targeting by antiviral DMXAA. Cell 154, 748-762.
32.Song, J., Teplova, M., Ishibe-Murakami, S. & Patel, D. J. (2012). Structure-based mechanistic insights into DNMT1-mediated maintenance DNA methylation. Science 335, 709-712.
33.Kuo, A. J., Song, J., Cheung, P., Ishibe-Murakami, S., Yamazoe, S., Chen, J., Patel, D. J. & Gozani, O. (2012). ORC1 BAH domain links dimethylation of H4K20 to DNA replication licensing and Meier-Gorlin syndrome. Nature 484, 115-119.
34.Ren, A., Rajashankar, K. & Patel, D. J. (2012). Fluoride ion encapsulation by Mg2+ and phosphates in a fluoride riboswitch. Nature 486, 85-89.
35.Nakanishi, K., Weinberg, D., Bartel, D. P. & Patel, D. J. (2012). Structure of yeast Argonaute with guide RNA. Nature 486, 368-374.
36.Kruidenier, L., Chung, C., Cheng, Z., Liddle, J., Bantscheff, M., Bountra, C., Bridges, A., Che, K., Diallo, H., Eberhard, D., Hutchinson, S., Joberty, G., Jones, E., Katso, R., Leveridge, M., Mosley, J., Rowland, P., Ramirez-Molina, C., Schofield, C. J., Sheppard, R., Smith, J. E., Swales, C., Tanner, R., Thomas, P., Tumber, A., Drewes, G., Oppermann, U., Patel, D. J., Lee, K., & Wilson, W. (2012). A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response. Nature 488, 404-408.
37.Du, J., Zhong, X., Barnatavichute, Y. V., Stroud, H., Feng, S., Caro, E., Vashisht, A. A., Terragni, J., Chin, H. G., Tu, J., Hetzel, J., Wohlschlegel, J. A., Pradhan, S., Patel, D. J. & Jacobsen, S. E. (2012). Dual binding of chromomethylase domains to H3K9me2-containing nucleosomes directs DNA methylation in plants. Cell 151,167-180.
38.Elsasser, S. J., Huang, H., Lewis, P. W., Allis, C. D. & Patel, D. J. (2012). DAXX histone chaperone envelops an H3.3/H4 dimer for H3.3-specific recognition. Nature 491, 560-565.
39.Song, J., Rechkoblit, O., Bestor, T. H. & Patel, D. J. (2011). Structure of DNMT1-DNA complex reveals a role for autoinhibition in maintenance DNA methylation. Science 331, 1036-1040.
40.Ruthenburg, A., Li, H., Milne, T., Dou, Y., McGinty, R. K., Yuen, M., Muir, T. W., Patel, D. J. & Allis, C. D. (2011). Recognition of a mononucleosomal histone modification pattern by BPTF via multivalent interactions. Cell 145, 692-706.
41.Weinberg, D., Nakanishi, K., Patel, D. J. & Bartel, D. P. (2011). The inside-out mechanism of Dicers from budding yeasts. Cell 146, 262-276.
42.Park, J. E., Heo, I., Tian, Y., Shimanshu, D., Chang, H., Jee, D., Patel, D. J. & Kim, V. N. (2011). Human Dicer recognizes the 5’-phosphorylated end of RNA for efficient and accurate cleavage. Nature 475, 201-205.
43.Wang, Z., Song, J., Milne, T. A., Wang, G. G., Li, H., Allis, C. D. & Patel, D. J. (2010). Pro isomerization in MLL1 PHD3-Bromo cassette connects H3K4me3 readout to CyP33 and HDAC-mediated repression. Cell 141, 1183-1194.
44.Tsai, W-W., Wang, Z., Yiu, T. T., Akdemir, K. C., Xia, W., Winter, S., Tsai, C-Y., Shi, X., Schwarzer, D., Plunkett, W., Aronow, B., Gozani, O., Fischle, W., Hung, M. C., Patel, D. J. & Barton, M. C. (2010). TRIM24 links recognition of a non-canonical histone signature to breast cancer. Nature 468, 927-932.
45.Wang, Y., Juranek, S., Li, H., Sheng, G., Wardle, G. S., Tuschl, T. Patel, D. J. (2009). Nucleation, propagation and cleavage of target RNAs in Ago silencing complexes. Nature 461, 754-761.
46.Wang, G. G., Song, J., Wang, Z., Dormann, H. L., Casadio, F., Li, H., Luo, J., Patel, D. J. & Allis, C. D. (2009). Haematopoietic malignancies initiated by dysregulation of a chromatin-binding PHD fineger. Nature 459, 847-851.
47.Serganov, A., Huang, L. & Patel, D. J. (2009). Coenzyme recognition and gene regulation by a FMN riboswitch. Nature 458, 233-237.
48.Xiao, A., Li, H., Shechter, D., Ahn, S. H., Fabrizio, L., Erajument-Bromage, H., Murakami-Ishibe, S., Wang, B., Tempst, P., Hofmann, K., Patel, D. J., Elledge, S. J. & Allis, C. D. (2009). WSTF regulates the DNA damage response of H2A.X via a novel tyrosine kinase activity. Nature 457, 57-62.
49.Wang, Y., Li, H., Juranek, S., Sheng, G., Tuschl, T. & Patel, D. J. (2008). Structure of an argonaute silencing complex with a seed-containing guide DNA and target RNA duplex. Nature 456, 921-926.
50.Wang, Y., Sheng, G., Juranek, S., Tuschl, T. & Patel, D. J. (2008). Structure of the guide-strand-containing argonaute silencing complex. Nature 456, 209-213.
51.Serganov, A., Huang, L. & Patel, D. J. (2008). Structural insights into ligand binding and gene control by a lysine riboswitch. Nature 455, 1263-1267. 

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