Southern University of Science and Technology (SUSTech) is a public university founded in the Shenzhen Special Economic Zone of China.
SUSTech offers an unparalleled learning and research experience at the scientific and technological frontiers.
SUSTech offers unprecedented opportunities for undergraduate and graduate students to work alongside the faculty to explore and tackle both fundamental and practical problems.
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The undergraduate admission of SUSTech adopts comprehensive evaluation enrollment mode based on national college entrance examination.The graduate admission of SUSTech currently adopts joint training mode.
The main duties of SUSTCEF is to accept the donations from the domestic and foreign associations, enterprises, trading companies and individuals, and establish the funding projects depending on the demands of the university and the wishes of the donors.
Mesenchymal stem cells (MSCs) can give rise to several cell lineages, including osteoblasts and adipocytes, and it is known that adhesive and mechanical cues from the microenvironment control cell fate decisions. In the Journal of Cell Biology, Guo et al. now report that kindlin-2 regulates MSC differentiation through the mechanosensitive transcription co-regulators YAP1 and TAZ.
This study indicates that kindlin-2 controls MSC differentiation in response to mechanical inputs by promoting actin stress fibre formation at integrin adhesions, increasing the levels and activity of YAP1 and TAZ and osteogenesis. These findings have important medical implications as an imbalance between osteogenesis and adipogenesis is the cause of many bone diseases.
Link to the paper: https://www.nature.com/articles/nrm.2018.21；
Source:Department of Biology