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Faculty

ZHANG WENYONG


Professor

Associated Director of Medical Education

School of Medicine

Room 504, Building B

zhangwy@sustc.edu.cn

Professor Zhang Wenyong is a molecular pathologist. He obtained a full scholarship to study at Bowdoin College in 1992 and graduated with the hightest distinction with a major in biochemistry. He was then admitted to the distinguished "Tri-institutional MD-PhD Program" at Cornell Medical School/Rockefeller University and Sloan Kettering Caner Institute. He graduated in 2004 with The Herman L. Jacobius Pathology Award.  During the PhD work, he studied in the lab of the world leading expert in HIV biology, Dr. David Ho, and pionnerred in developing a potent HIV DNA vaccine by targeting dendritic cells. He received Elizabeth Glaser Pediatric AIDS Foundation Student Award for his work. He obtained residency training in anatomic pathology from Cornell Medical School- New York Presbyterian Hospital, and continued with a fellowhip in molecular pathology at Baylor College of Medicine/MD Anderson Cancer Center in Houston. He was then appointed Associated Director of molecular pathology laboratory at Mt. Sinai School of Medicine in 2008 and Director of Molecular Pathology Laboratory at New York Medical Collage Hospital in 2010. He has developed a number of highly accurate and effient methods for detecting molecular changes associated with cancer.

 

Book Chapters:

J. Zhuge, W. Zhang. Principles of molecular biology in Molecular Diagnosis of Skin Diseases (M. Murphy, ed). Humana Press (2011).

 

Peer Reviewd Journal Articles:

1、Luo A, Cheng D, Yuan S, Li H, Du J, Zhang Y, Yang C, Lin G, Zhang W, Tan YQ. Maternal interchromosomal insertional translocation leading to 1q43-q44 deletion and duplication in two siblings. Mol Cytogenet. 2018 Apr 4;11:24 (共同通讯作者).

2、T. Huang, J. Zhuge, W. Zhang. Sensitive detection of BRAF V600E mutation by Amplification Refractory Mutation System (ARMS)-PCR. Biomarker Research 2013; 1:3

3、Li Z, Cai X, Cai CL, Wang J, Zhang W, Petersen BE, Yang FC, Xu M. Deletion of Tet2 in mice leads to dysregulated hematopoietic stem cells and subsequent development of myeloid malignancies. Blood. 2011 Oct 27;118(17):4509-18

4、L. Varricchio, E. Masselli, E. Alfani, W. Zhang, R. Hoffman, AR Migliaccio. The dominant negative b isoform of the glucocorticoid receptor is uniquely expressed in erythroid cells. Blood 2011, 118(2): 425-36

5、J. Zhuge, W. Zhang. Sensitive detection of MPLW515L/K mutations by amplification refractory mutation system (ARMS)-PCR. Clinica Chimica Acta 2010; 411:122-123

6、W. Zhang, D. Jones. Predictors of primary imatinib resistance in chronic myeloid leukemia are distinct from those in secondary resistance. J Clin Oncology 2009; 27: 3642-3649

7、W. Zhang, D. López-Terrada. Molecular monitoring of 8p11 myeloproliferative syndrome in an infant. J Pediatr Hematol Oncol 2009;31:879-883

8、W. Wang, E. Mayordomo, W. Zhang, V. S. Hernandez, D. Tuvin, L. Garcia, D. C. Lev, A. J. F. Lazar, D. López-Terrada. Detection and characterization of EWSR1/ATF1 and EWSR1/CREB1 chimeric transcripts in Clear Cell Sarcoma (Melanoma of Soft Parts). Modern Pathology 2009; 22:1201-1209

9、Z. Chen, W. Zhang, D. Ho. Design, construction, and characterization of a multigenic modified vaccinia Ankara candidate vaccine against human immunodeficiency virus type 1 subtype C/B'. JAIDS 2008; 47: 412-421.

10、Y. Huang, Z. Chen, W. Zhang, D. Gurner, Y. Song, D. Gardiner, D. D. Ho. Design, construction, and characterization of a dual-promoter multigenic DNA vaccine directed against an HIV-1 subtype C/B' recombinant. JAIDS 2008; 47: 403-411.

11、Y. Huang, A. Chen, X. Li, Z. Chen, W. Zhang, Y. Song, D. Gurner, D. Gardiner, S. Basu, D. D. Ho and M. Tsuji. Enhancement of HIV DNA vaccine immunogenicity by the NK T cell ligand, -galactosylceramide. Vaccine 2008; 26:1807-1816.

12、W. Zhang, J. Versalovic. Expanding the diagnostic capabilities of molecular microbiology by genomic methods. Journal of Molecular Diagnostics 2007; 9(5): 572-573.

13、W. Zhang, J. E. Dahlberg, W. Tam. MicroRNAs in tumorigenesis: a primer for pathologists. American Journal of Pathology 2007; 171(3):728-738.

14、W. Zhang, H. Syed. Mammary small cell carcinoma with dimorphic phenotype. Breast Journal 2007; 13(5): 529-530.

15、L. Zhang, W. Yu, T. He, J. Yu, R. E. Caffrey, E. A. Dalmasso, S. Fu, T. Pham, J. Mei, J. J. Ho, W. Zhang, P. Lopez, D. D. Ho. Contribution of human {alpha}-Defensin-1, -2 and -3 to the anti-HIV-1 activity of CD8 antiviral factor. Science 2002; 298:995-1000.

16、B. Stibrková, J. Majewski, I. Sebesta, W. Zhang, J. Ott, S. Kmoch. Familial juvenile hyperuricemic nephropathy: localization of the gene on chromosome 16p11.2-and evidence for genetic heterogeneity. Am. J. Human Genetics 2000; 66:1989-1994.

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