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Faculty

Zhang Yandong


Assistant Professor

Department of Biolgoy

0755-88018422

zhangyd@sustc.edu.cn

Self-introduction:

Dr. Yandong Zhang obtained Ph.D from Washington State University (Pullman, WA) in 2007. She did her postdoctoral research at the Department of Molecular Oncology, Washington University in St. Louis from 2008 to 2013. Her research interests focus on the molecular mechanisms of cellular transformation by mutations of tumor suppressors and oncogenes. Several major publications were on Molecular Cellular Biology, Oncogene,Molecular Cancer Research and Breast Cancer Research.

 

Professional Experience:

◆2013.8- now, Assistant Professor, Department of Biology, SUSTC.

◆2008-9-2013.5, Postdoctoral Associate, Department of Molecular Oncology, Washington University, St. Louis, School of Medicine

 

Educational Background:

◆2007 Ph.D , Biochemistry, Washington State University

◆2000 MS, Biochemistry, Jilin University

◆1997 BS, Biochemistry, Jilin University, School of Life Sciences

 

Honors & Awards:

◆ Shenzhen Peacock Program, 2014

 

Selected Publication:

1.Li-Qiang Zhang, Yan-Dong Zhang, Li Xu, Xiang-Lu Li, Xue-cheng Yang, Guang- Li Xu Xiao-Xia Wu, Hong-Yin Gao, Wei-Bin Du, Xue-Tao Zhang,  Xue-Zhong Zhang*, Lipase-Catalyzed Synthesis of RGD diamide in Aqueous Water-Miscible Organic Solvents. Enzyme Microb.Technol., 29: 129-135, 2001.

2.Zhang, Y., Wang, Z., Magnuson, NS. (2007)  Pim-1 kinase-dependent phosphorylation of p21Cip1/WAF1 regulates its stability and localization in H1299 cells. Mol. Can. Res.  5 (9): 909-922

3.Zhang, Y., Wang, Z., Li, X., Magnuson, NS. (2008) Pim kinase-dependent inhibition of c-Myc degradation. Oncogene   27:4809-4819

4.Wang, Z., Zhang, Y., Gu, JJ., Davitt, C., Reeves, R., Magnuson, NS. (2010) Pim-2 phosphorylation of p21(Cip1/WAF1) enhances its stability and inhibits cell proliferation in HCT116 cells.  Int J Biochem Cell Biol. 42(6):1030-8

5.Zhang, Y., Forys, JT., Miceli, A., Gwinn, A., Weber, JD. (2011) Identification of DHX33 as a mediator in rRNA synthesis and cell growth. Molecular Cellular Biology (spotlight) 2011,  31 (23), 4676-4691,

6.Zhang,Y.,  Saporita,A., Weber, JD.  p19ARF and Ras V12 offer opposing regulation of DHX33 translation to dictate tumor cell fate.  Molecular Cellular Biology 2013 Apr; 33(8):1594-607.

7.Zhang,Y., Baysac, KC.,  Yee, LY., Saporita AJ., and Weber, JD Elevated DDX21 Regulates c-Jun Activity and rRNA Processing in Human Breast Cancers.  Breast Cancer Research  2014, Sep. 28;16(5):449

8.Zhang,Y*., You, J., Wang, XS., Weber, JD* DHX33 protein interacts with cytosolic translation initiation factors and ribosomes to promote mRNA translation. Molecular Cellular Biology Sep 1, 2015;35(17):2918-31 *, corresponding author

9.Wu, C.*, You, J. , Fu, J. , Wang, XS, Zhang, Y*. PI3K/Akt mediates integrin signaling to control RNA polymerase I transcription. Molecular Cellular Biology, 2016, 36 (10), *, corresponding author

10.Yuan, BL., Wang, XS., Fan, CY., You, J., Liu, YC., Weber, JD., Zhong, HB*., Zhang, Y*.   DHX33 transcriptionally controls genes involved in cell cycle. Molecular Cellular Biology 2016 Sep 6. pii: MCB.00314-16. [Epub ahead of print]  *, corresponding author

11.You, J., Wang, XS., Wang, JL., Yuan, BL., Zhang, Y#. DDX59 promotes DNA replication in lung adenocarcinoma,  Cell Death and Discovery, accepted, Nov,2016, #, corresponding author

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