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Home > Faculty > SUSTech Faculty Finder > Xiao Guozhi


Xiao Guozhi


Department of biology



Professor Guozhi Xiao is an internationally renowned bone biologist. He made several important contributions to our understanding of transcriptional control of osteoblast and osteoclast formation. His work is reported in more than 70 peer-reviewed publications, many in high profile journals such as the Journal of Clinical Investigation, the Journal of Biological Chemistry, Molecular Endocrinology, Endocrinology, Cancer Research, the Journal of Cell Biology, the Journal of Bone and Mineral Research, and Blood. Consistent with the high regard the scientific community has for Dr. Xiao, he serves as a reviewer for the US National Science Foundation, the Italian Ministry of Health and the National Natural Science Foundation of China and is on the Editorial Boards of the Journal of Bone and Mineral Research and the Journal of Biological Chemistry.


Educational background:

1979-1984:Nanchang University School of Medicine, Bachelor Degree of Medicine。

1985-1988:Peking University Health Sciences Center, Department of Biochemistry and Molecular Biology, Master Degree.

1991-1994:Peking University Health Sciences Center, Department of Biochemistry and Molecular Biology, Ph.D. 


Professional experience:

1994-1995:Post doctor, University of Michigan School of Medicine (Ann Arbor).

1994-1998:Post doctor, University of Michigan School of Dentistry (Ann Arbor).

1998-2004: Instructor, University of Michigan School of Dentistry (Ann Arbor). 

2004-2005: Research assistant professor, University of Michigan School of Dentistry (Ann Arbor).

2005-2011: Assistant professor (tenure track), University of Pittsburgh School of Medicine (Pittsburgh).

2011-2011: Associate professor (with tenure), University of Pittsburgh School of Medicine (Pittsburgh).

2012:     Associate professor, Rush University Medical Center. Director of research (Dept of Biochemistry) 

2012:     Ralph and Marian C. Falk Endowed Professor of Biochemistry of Rush University.


Selected publications:

Original full-length peer-reviewed research papers (H-index=36, total citations=6226 on Google citation as of Jan 18, 2016)
1. Xiao G, Jia H., and Zhang N, and Schmidt J. Activation of the chick muscle acetylcholine receptor ã-subunit distal upstream sequence depends on the expression of myogenic factors.Chin J Biochem Mol Biol. 1995; 11(5): 521-524.
2. Xiao G, Jia H, and Zhang N, and Schmidt J. Interaction of distal E boxes of chick nicotinic acetylcholine receptor ã-subunit gene with myogenin. Chin J Biochem Mol Biol. 1995;11(5): 516-520.
3. Walke W, Xiao G, and Goldman D. A dual function activity-dependent, muscle-specific enhancer from rat nicotinic acetylcholine receptor ä-subunit gene. J Neurobiol. 1996; 31(3):359-369.
4. Walke W, Xiao G, and Goldman D. Identification and characterization of a 47 base pair activity-dependent enhancer of the rat nicotinic acetylcholine receptor ä-subunit promoter. J Neurosci. 1996; 16(11): 3641-3651.
5. Xiao G, Cui Y, Ducy P, Karsenty G, and Franceschi RT. Ascorbic acid-dependent activation of the osteocalcin promoter in MC3T3-E1 preosteoblasts: requirement for collagen matrix synthesis and the presence of an intact OSE2 sequence. Mol Endocrinol. 1997; 11:1103-1113.
6. Xiao G, Wang D, Benson MD, Karsenty G, and Franceschi RT. Role of the á2 integrin in osteoblast-specific gene expression and activation of the Osf2 transcription factor. J Biol Chem. 1998; 273, 32988-32994.
7. Frendo JL, Xiao G, Fuches S, Franceschi RT, Karsentry G, and Ducy P. Functional hierarchy between two OSE2 elements in the control of osteocalcin expression in vivo. J Biol Chem. 1998; 273, 30509-30516.
8. Wang D, Christensen, K, Chawla, K, Xiao G, Krebsbach P. and Franceschi, RT. Isolation and characterization of MC3T3-E1 murine preosteoblast subclones with distinct in vitro and in vivo differentiation/mineralization potential. J Bone Miner Res, 1999; 14:893-903.
9. Li D, Jia H, Xiao G, Schmidt J. Interaction between acetylcholine receptor γ-subunit promotor and nuclear factors in differentiated and undifferentiated muscle cells. Chin J Biochem Mol Biol. 1998; 14(4):353~ 357.
10. Benson MD, Aubin JE, Xiao G, Thomas PE, and Franceschi RT. Cloning of a 2.5 kb murine bone sialoprotein promoter fragment and functional analysis of putative Cbf/runt binding sites. J Bone Miner Res. 1999; 14:396-405.
11. Xiao G, Jiang D, Thomas PE, Benson MD, Guan KL, Karsenty G, and Franceschi RT. MAPK pathways activate and phosphorylate the osteoblast-specific transcription factor, Osf2/Cbfa1. J Biol Chem. 2000; 275, 4453-4459.
12. Benson MD, Bargeon JL, Xiao G, Thomas PE, Ahn Kim, Yingqi Cui, and Franceschi RT. Identification of a homeodomain binding element in the bone sialoprotein gene promoter which is required for its osteoblast-selective expression. J Biol Chem. 2000; 275: 13907-13917.
13. Ma PX, Zhang R, Xiao G, and Franceschi RT. Engineering new bone tissue in vitro on highly pore poly(-hydroxyl acids)/hydroxyapatite composite scaffolds. J Biomed Mater Res. 2001; 54:284-293.
14. Xiao G, Jiang D, Gopalakrishnan R, and Franceschi RT. FGF-2 induction of the osteocalcin gene requires MAPK activity and phosphorylation of the osteoblast transcription factor, Cbfa1/Runx2. J Biol Chem. 2002; 277:36181-36187.
15. Zhao M, Xiao G, Berry J, Franceschi RT, Reddi A, and Somerman MJ. Bone Morphogenetic Protein 2 induces dental follicle cells to differentiate toward a cementoblast/osteoblast phenotype. J Bone Miner Res. 2002; 17:1441-1451.
16. Xiao G, Gopalakrishnan R, Jiang D, Reith E, Benson MD, and Franceschi RT. BMP, extracellular matrix, and MAP kinase signaling pathways are required for osteoblast-specific gene expression and differentiation in MC3T3-E1 cells. J Bone Miner Res. 2002; 17:101-110.
17. Chen C, Koh AJ, Datta NS, Zhang J, Even ET, Xiao G, Franceschi RT, D'Silva NJ, and McCauley LK. Impact of mitogen-activated protein kinase (MAPK) pathway on parathyroid hormone related protein actions in osteoblasts. J Biol Chem. 2004; 279, 29121-29129.
18. Jiang D, Franceschi RT, Boules H, and Xiao G. Parathyroid Hormone Induction of the Osteocalcin Gene: requirement for an osteoblast-specific element 1 sequence in the promoter and involvement of multiple signaling pathways. J Biol Chem. 2004; 279:5329-5337.
19. Xiao G, Jiang D, Ge C, Zhao Z, Boules H, Phimphilai M, Yang X, Karsenty G, and Boules H, Franceschi RT. Cooperative interactions between ATF4 and Runx2/Cbfa1 stimulate osteoblast-specific osteocalcin gene expression. J Biol Chem, 2005; 280:30689-30696.
20. Roca H, Phimphilai M, Gopalakrishnan R, Xiao G, and Franceschi RT. Cooprative interactions between RUNX2 and homeodomain protein binding sites are critical for the osteoblastspecific expression of the bone sialoprotein gene. J Biol Chem, 2005; 280:30845-30855.
21. Zhao Z, Zhao M, Xiao G, and Franceschi RT. Gene transfer of the Runx2 transcription factor enhances osteogenic activity of bone marrow stromal cells in vitro and in vivo. Mol Ther. 2005; 12(2):247-53.
22. Lu, Y, Cai Z, Galson DL, Xiao G, Liu, Y, George DE, Melhem MF, Yao Z, Zhang J. Monocyte chemotactic protein-1 (MCP-1) acts as a paracrine and autocrine factor for prostate cancer growth and invasion. Prostate. 2006; 66(12): 1311-8.
23. Zhu J, Jia X, Xiao G, Kang Y, Partridge, NC, Qin L. EGF-like ligands stimulate osteoclastogenesis by regulating expression of osteoclast regulatory factors in osteoblasts: implications in osteolytic bone metastases. J Biol Chem. 2007; 282(37): 26656-64.
24. Singha UK, Jiang Y. Yu S, Luo M, Lu Y, Zhang J, Xiao G. Rapamycin inhibits osteoblast proliferation and differentiation in MC3T3-E1 cells and primary mouse bone marrow stromal cells. J Cell Biochem. 2007; 103(2): 434-46.
25. Lu Y, Xiao G, Galson DL, Nishio Y, Mizokami A, Keller E, Yao Z, and Zhang J. PTHrPinduced production of monocyte chemoattractant protein-1 (MCP-1) by human bone marrow endothelial cells and osteoblasts promotes osteoclast differentiation in vitro: a novel role in prostate cancer bone metastasis. Int J Cancer. 2007; 121(4): 724-733.
26. Lu Y, Cai Z, Xiao G, Liu Y, Keller E, Yao Z, and Zhang J. CCR2 expression correlates with prostate cancer progression. J Cell Biochem. 2007; 101(3): 676-85.
27. Lu Y, Cai Z, Xiao G, Yao Z, Anderson JL, Roodman DG, and Zhang J. Prostate cancer cells induce osteoclastogenesis and bone resorption through RANKL-independent interleukin-8 (IL-8) and monocyte chemoattractant protein-1 (MCP-1) production. Cancer Res. 2007;67(8): 3646-53.
28. Ge C, Xiao G, Jiang D, and Franceschi RT. Critical role of extracellular signal-regulated kinase/MAPK pathway in osteoblast differentiation and skeletal development. J Cell Biol.2007; 176(5): 709-818. PMCID: PMC2064027.
29. Feng, R, Anderson G, Xiao G, Elliot G, Leoni L, Lapara MY, Roodman GD, and Lentzsch S. SDX-308, a non-steroidal anti-inflammatory agent, inhibits NF-êB activity resulting in strong inhibition of osteoclast formation/activity and multiple myeloma cell growth. Blood.2007; 109(3): 2130-2138.
30. Yu S, Franceschi RT, Luo M, Zhang X, Jiang D, Lai Y, Jiang Y, Zhang J, Xiao G. Parathyroid hormone increases activating transcription factor 4 expression and activity in osteoblasts: requirement for osteocalcin gene expression. Endocrinology. 2008; 149(4): 1960-8. PMCID: PMC2276723.
31. Yu S, Jiang Y, Galson DL, Luo M, Lai Y, Lu Y, Ouyang HJ, Zhang J, Xiao G. General transcription factor IIA-gamma increases osteoblast-specific osteocalcin gene expression via activating transcription factor 4 and runtrelated transcription factor 2. J Biol Chem. 2008; 283(9): 5542-53. PMCID: PMC2736298.
32. Zhang X, Yu S, Galson, DL, Luo M, Fan J, Zhang J, Guan Y, Xiao G. Activating transcription factor 4 is critical for proliferation and survival in primary bone marrow stromal cells and calvarial osteoblasts. J Cell Biochem. 2008; 105(3): 885-95. PMCID: PMC2704124.
33. Liu Y, Yuan Y, Li Y, Zhang J, Xiao G, Vodovotz Y, Billiar TR, Wilson M, Fan J. Interacting neuro-endocrine, innate, and acquired immune pathways regulate neutrophil from bone
marrow following hemorrhage shock, J Immnol. 2009;182(1):572-580. PMCID: PMC2610356.
34. Cai, Z, Chen Q, Chen J, Lu Y, Xiao G, Wu Z, Zhou Q, Zhang J. Monocyte chemotactic protein-1 promotes lung cancer-induced bone resorptive lesion in vivo. Neoplasia. 2009;11(3):228-36. PMCID: PMC2647725.
35. Yu S, Franceschi RT, Luo M, Fan J, Jiang D, Cao H, Lai Y, Zhang J, Patrene K, Hankenson KD, Roodman GD, Xiao G. Critical role of activating transcription factor 4 in the anabolic actions of PTH in bone. PLoS One. 2009, Oct 23;4(10):e7583. PMCID: PMC2762317. (This paper was listed as the No. 1 "Not to be Missed" paper in the November (2009) issue of the IBMS BoneKEy, BoneKEy is published by the International Bone & Mineral Society, link:
36. Ge C, Xiao G (co-first author), Jiang D, Yang Q, Hatch NE, and Franceschi RT. Identification and functional characterization of extracellular-regulated kinase/MAPK phosphorylation sites in the Runx2 transcription factor. J Biol Chem. 2009; 284(47):32533-43. PMCID: PMC2781667.
37. Li Y, Xiang M, Yuan Y, Xiao G, Zhang J, Vodovotz Y, Billiar TR, Wilson MA, and Fan J. HMGB1 upregulation of TLR2 augments hemorrhagic shock-Induced ICAM-1 expression in lung endothelial cells. Am J Physiol Regul Integr Comp Physiol. 2009; 297(6):R1670-80, PMCID: PMC2803625.
38. Cao H, Yu S, Yao Z, Galson DL, Jiang Y, Zhang X, Fan J, Lu B, Guan Y, Luo M, Lai Y, Zhu, Y, Kurihara N, Patrene K, Roodman GD, Xiao G. Activating transcription factor 4 regulates osteoclast differentiation in mice. J Clin Invest. 2010 Aug 2;120(8):2755-66. PMCID: PMC2912190.
39. Wu, Z, Jiao P, Huang, X, Feng Y, Feng B, Yang S, Hwang P, Du J, Hall RK, Xiao G, Xu H. MAP kinase phosphatase 3 regulates glucose homeostasis through dephosphorylation of FOXO1 in mice. J Clin Invest. 2010 Nov 1;120(11):3901-11. PMCID: PMC2964981.
40. Xiang M, Yin L, Li Y, Xiao G, Vodovotz Y, Billiar TR, Wilson MA, and Fan J. Hemorrhagic shock activates lung endothelial NAD(P)H oxidase via neutrophil NADPH oxidase. Am J Respir Cell Mol Biol. 2011 Mar;44(3):333-40. PMCID: PMC3095934.
41. Yang S, Xu H, Yu S, Cao H, Jie Fan, Ge C, Fransceschi RT, Dong HH, Xiao G. Foxo1 mediates IGF1/Insulin regulation of osteocalcin expression by antagonizing Runx2 in osteoblasts, J Biol Chem. 2011; 286(21):19149-58. PMCID: PMC3099728.
42. Xiang M, Shi X, Li Y, Xu J, Yin L, Xiao G, Scott MJ, Billiar TR, Wilson MA, and Fan J. Hemorrhagic shock activation of NLRP3 inflammasome in lung endothelial cells. J Immnol. 2011; 187(9) :4809-17, PMCID: PMC3197874.
43. Danciu TH, Li Y, Koh A, Xiao G, McCauley LK, Franceschi RT. The basic helix loop helix transcription factor Twist1 is a novel regulator of ATF4 in osteoblasts, J Cell Biochem. 2011;113(1):70-9. PMCID: PMC3414260.
44. D'Souza S, Del Prete D, Jin S, Sun Q, Huston AJ, Kostov FE, Sammut B, Hong CS, Anderson JL, Patrene KD, Yu S, Velu CS, Xiao G, Grimes HL, Roodman GD, Galson DL. Gfi-1 expressed in bone marrow stromal cells is a novel osteoblast suppressor in patients with multiple myeloma bone disease, Blood. 2011;118(26):6871-80. PMCID: PMC3245209.
45. Tang W, Yang F, Li Y, de Crombrugghe B, Jiao H, Xiao G, and Zhang C. Transcriptional regulation of vascular endothelial growth factor (VEGF) by osteoblast-specific transcription factor osterix (Osx) in osteoblasts. J Biol Chem. 2012 Jan 13;287(3):1671-8. PMCID: PMC3265850.
46. Xiang M, Yuan Y, Fan L, Li Y, Li A, Yin L, Scott MJ, Xiao G, Billiar TR, Wilson MA, Fan J. Role of Macrophages in Mobilization of Hematopoietic Progenitor Cells From Bone Marrow After Hemorrhagic Shock. Shock. 2012 May;37(5):518-523. PMCID: PMC3328610.
47. Li X, Ellman MB, Kroin JS, Chen D, Yan D, Mikecz K, Kc R, Xiao G, Stein GS, Kim SG, Cole B, van Wijnen AJ, Im HJ. Species-specific biological effects of FGF-2 in articular cartilage: Implication for distinct roles within the FGF receptor family. J Cell Biochem. 2012 Jul;113(7):2532-42. PMCID: PMC3349778.
48. Xiao G, Cheng H, Cao H, Chen K, Tu Y, Yu S, Jiao H, Yang S, Im HJ, Chen D, Chen J, Wu C. Critical role of Filamin-binding LIM protein 1 (FBLP-1)/migfilin in regulation of bone remodeling. J Biol Chem. 2012 June 15;287(25):21450-60. PMCID: PMC3375566.
49. Ellman MB, Kim JS, An HS, Chen D, Ranjan KC, An J, Dittakavi T, van Wijnen AJ, CsSzabo G, Li X, Xiao G, An S, Kim SG, Im HJ. Toll-like receptor adaptor signaling molecule MyD88 on intervertebral disc homeostasis: in vitro, ex vivo studies. Gene. 2012 Sep 1;505(2):283-90, PMCID: PMC3518428.
50. Yan D, Chen D, Xiao G, van Wijnen A, Im HJ. Bovine lactoferricin, an antimicrobial peptide, is anti-inflammatory and anti-catabolic in human articular cartilage and synovium. J Cell Physiol. 2013 Feb;228(2):447-56, PMCID: PMC3463726.
51. Meng M, Jin H, Wang B, Yukata K, Sheu TJ, Ke QH, Tong P, Im HJ, Xiao G, Chen D. Chondrocyte BMP-2 Signaling Plays a Critical Role in Bone Fracture Healing. Gene. 512 (2013) 211–218. PMCID: PMC3531824.
52. Yu S, Sharma R, Nie D, Jiao H, Lai Y, Fan J, Im HJ, Chen D, Wang Q, Xiao G. ADAR1 is required for osteoblast differentiation and bone homeostasis. Gene. 513 (2013) 101–110. PMCID: PMC3514579.
53. Yu S, Zhu K, Lai Y, Zhao Z, Fan J, Im HJ, Chen D, Xiao G. ATF4 promotes β-catenin expression and osteoblastic differentiation of bone marrow mesenchymal stem cells. Int J Biol Sci. 2013; 9(3):256-266. PMCID: PMC3596711.
54. Xu P, Wen Z, Shi X, Li Y, Fan L, Xiang M, Li A, Scott MJ, Xiao G, Li S, Billiar TR, Wilson MA, Fan J. Hemorrhagic shock augments Nlrp3 inflammasome activation in the lung through iompaired pyrin induction. J Immunol. 2013 May 15;190(10):5247-55. PMCID: PMC3646900.
55. Kim JS, Ellman MB, Yan D, An HS, Kc R, Li X, Chen D, Xiao G, Cs-Zabo G, Hoskin DW, Buechter DD, van Wijnen AJ, Im HJ. Lactoferricin mediates anti-inflammatory and anticatabolic effects via inhibition of IL-1 and LPS activity in the intervertebral disc. J Cell Physiol. 2013 Sep;228(9):1884-96. PMCID: PMC3703102.
56. Ellman MB, Kim J, An HS, Chen D, Kc R, Li X, Xiao G, Yan D, Suh J, van Wijnen A, Wang J, Kim S, Im H. Lactoferricin enhances BMP7-stimulated anabolic pathways in intervertebral disc cells. Gene. 2013 Jul 25;524(2):282-91. PMCID: PMC3679319.
57. Liu Z, Jiang Y, Li Y, Wang J, Fan L, Scott MJ, Xiao G, Li S, Billiar TR, Wilson MA, Fan J. TLR4 signaling augments monocyte chemotaxis by regulating G protein-coupled receptor kinase 2 translocation. J Immunol. 2013 Jul 15;191(2):857-64. PMCID: PMC3702632.
58. Zheng L, Zhu K, Jiao H, Zhao Z, Zhang L, Liu M, Chen D, Yao Z, Xiao G. PTHrP expression in human MDA-MB-231 breast cancer cells is critical for tumor growth and survival and osteoblast inhibition. Int J Biol Sci. 2013 Aug 21;9(8):830-41. PMCID: PMC3753447.
59. Xiao G, Zhang T, Yu S, Lee A, Calabuig-Navarro V, Ringquist S, Dong HH. ATF4 deficiency protects against high fructose-induced hypertriglyceridemia in mice. J Biol Chem. 2013 Aug 30;288(35):25350-61. PMCID: PMC3757199.
60. Zhu K, Jiao H, Li S, Cao H, Galson DL, Zhao Z, Zhao X, Lai Y, Fan J, Im HJ, Chen D, Xiao G. ATF4 promotes bone angiogenesis by increasing VEGF expression and release in the bone environment. J Bone Miner Res. 2013;28: 1870–1884. PMID: 23649506. EDITOR'S CHOICE paper of September 2013 JBMR issue with a notation on the cover and with a commentary as well. For a Commentary on this article, please see Schipani et al. (J Bone Miner Res. 2013;28:1866-1869. DOI: 10.1002/jbmr.2045).
61. Cao H, Zhu K, Qiu L, Li S, Niu H, Hao M, Yang S, Zhao Z, Lai Y, Anderson JL, Fan J, Im HJ, Chen D, Roodman GD, Xiao G. Critical role of AKT in myeloma-induced osteoclast formation and osteolysis. J Biol Chem. 2013 Oct 18;288(42):30399-410. PMCID: PMC3798504.
62. Yan D, Kc R, Chen D, Xiao G, Im H. Bovine lactoferricin-induced anti-inflammation is, in part, via upregulation of IL-11 by secondary activation of STAT3 in human articular cartilage. J Biol Chem. 2013 Nov 1;288(44):31655-69. PMID: 24036113.
63. Wang B, Jin H, Zhu M, Li J, Zhao L, Zhang Y, Tang D, Xiao G, Xing L, Boyce BF, Chen D Chondrocyte β-catenin signaling regulates postnatal bone remodeling through modulation of Rankl/Opg expression and osteoclast differentiation. Arthritis Rheumatol. 2014 Jan;66(1):107-20. doi: 10.1002/art.38195. PMID: 244312822.
64. Li TF, Yukata K, Yin G, Sheu T, Maruyama T, Jonason JH, Hsu W, Zhang X, Xiao G, Konttinen YT, Chen D, O'Keefe RJ. BMP-2 regulates chondrocyte differentiation through modulation of COX-2 and ATF4. Osteoarthritis and Cartilage. 2014 Mar;22(3):481-9. PMID: 24418675.
65. Li S, Shu B, Zhang Y, Li J, Guo J, Wang Y, Ren F, Xiao G, Chang Z, Chen D. CHIP regulates osteoclast formation through promoting TRAF6 protein degradation. Arthritis Rheumatol. 2014 Jul;66(7):1854-63. doi: 10.1002/art.38521. PMID: 24578159.
66. Xu J, Jiang Y, Wang J, Shi X, Liu Q, Liu Z, Li Y, Scott MJ, Xiao G, Li S, Fan L, Billiar TR, Wilson MA, Fan J. Macrophage endocytosis of high-mobility group box 1 triggers pyroptosis. Cell Death Differ. 2014 Aug;21(8):1229-39. PMID: 24769733. PMCID: PMC4085529.
67. Qu H, Tu Y, Guan JL, Xiao G, Wu C. Kindlin-2 tyrosine phosphorylation and interaction with Src serve as a regulatable switch in the integrin outside-in signaling circuit. J Biol Chem. 2014 Nov 7;289(45):31001-13. PMID: 2523719.
68. Wen Z, Fan L, Li Y, Zou Z, Scott MJ, Xiao G, Li S, Billiar TR, Wilson MA, Shi X, Fan J. Neutrophils counteract autophagy-mediated anti-inflammatory mechanisms in alveolar macrophage: role in posthemorrhagic shock acute lung inflammation. J Immunol. 2014 Nov 1;193(9):4623-33. PMID: 25267975
69. Niu NK, Wang ZL, Pan ST, Ding HQ, Au GHT, He ZX, Zhou ZW, Xiao G, Yang YX, Zhang X, Yang T, Chen XW, Qiu JX, Zhou SF. Pro-apoptotic and pro-autophagic effects of the Aurora kinase A inhibitor alisertib on human osteosarcoma U-2 OS and MG-63 cells through the activation of mitochondria-mediated pathway and inhibition of p38 MAPK/PI3K/Akt/mTOR signaling pathway. Drug Des Devel Ther. 2015 Mar 12;9:1555-84. PMID: 25792811
70. Zhu K, Yi J, Xiao Y, Lai Y, Song P, Zheng W, Jiao H, Fan J, Wu C, Chen D, Zhou J, Xiao G. Impaired bone homeostasis in amyotrophic lateral sclerosis mice with muscle atrophy. J. Biol. Chem. 2015 Mar 27;290(13):8081-94. doi: 10.1074/jbc.M114.603985. Epub 2015 Feb 3. PMID: 25648889
71. Wu C, Jiao H, Lai, Y Zheng W, Chen K, Deng W, Song P, Zhu K, Cao H, Galson DL, Fan J, Im HJ, Liu Y, Chen J, Chen D, Xiao G. Kindlin-2 controls TGF-β signaling and Sox9 expression to regulate chondrogenesis. Nat Commun. 2015 Jul 7;6:7531. doi: 10.1038/ncomms8531. PMID: 26151572
72. Kim JS, Ahmadinia K, Li X, Hamilton JL, Andrews S, Haralampus CA, Xiao G, Sohn HM, You JW, Seo YS, Stein GS, Van Wijnen AJ, Kim SG, Im HJ. Development of an experimental animal model for lower back pain by percutaneous injury-induced lumbar facet joint osteoarthritis. J Cell Physiol. Nov;230(11):2837-47. doi: 10.1002/jcp.25015. PMID: 25858171
73. Qin TT, Xu GC, Qi JW, Yang GL, Zhang K, Liu HL, Xu LX, Xiang R, Xiao G, Cao H, Wei Y, Zhang QZ, Li LY. Tumor necrosis factor superfamily member 15 (Tnfsf15) facilitates lymphangiogenesis via upregulation of Vegfr3 gene expression in lymphatic endothelial cells. J Pathol. 2015 Nov;237(3):307-18. doi: 10.1002/path.4577. Epub 2015 Aug 6. PMID: 26096340
74. Zhao Y, Zhou J, Liu D, Dong F, Cheng H, Wang W, Pang Y, Wang Y, Mu X, Ni Y, Li Z, Xu H, Hao S, Wang X, Ma S, Wang QF, Xiao G, Yuan W, Liu B, Cheng T. ATF4 plays a pivotal role in the development of functional hematopoietic stem cells in mouse fetal liver. Blood. 2015 Nov 19;126(21):2383-91. doi: 10.1182/blood-2015-03-633354. Epub 2015 Sep 17. PMID: 26384355
75. Kim JS, Ali MH, Wydra F, Li X, Hamilton JL, An HS, Cs-Szabo G, Andrews S, Moric M, Xiao G, Wang JH, Chen D, Cavanaugh JM, Im HJ. Characterization of degenerative human facet joints and facet joint capsular tissues. Osteoarthritis and Cartilage. 2015 Dec;23(12):2242-51. PMID: 26117175, PMCID: PMC4663154
76. Ranjan Kc, Xin Li, Jeffrey Kroin, Zhiqiang Liu, Di Chen, Guozhi Xiao, Brett Levine, Jinyuan Li, John Hamilton, André van Wijnen, Margaret Piel, Daniel A Shelly, Dovrat Brass, Ela Kolb, Hee-Jeong ImPKCδ Null Mutation In Mice Alters Osteoarthritic Pain Independent of Joint Pathology By Augmenting NGF/TrkA-Induced Axonal Outgrow. Annals of the Rheumatic Diseases..acepted
77. Franceschi RT and Xiao G. Regulation of osteoblast-specific transcription factor, Runx2: Responsiveness to multiple signal transduction pathways. J Cell Biochem. 2003; 88:446-454.
78. Franceschi RT. Xiao G, Thomas PE, Jiang D, and Benson MD. Extracellular matrix regulation of osteoblast-specific gene expression: role of the á2â1 integrin and Osf2/Cbfa1. Chemistry and Biology of Mineralized Tissues: Connect Tissue Res. 2000;41 Suppl 1:249-254.
79. Franceschi RT. Xiao G, Jiang D, Gopalakrishnan R, Yang S and Reith E. Multiple signaling pathways converge on the Cbfa1/Runx2 transcription factor to regulate osteoblast differentiation: Connect Tissue Res. 2003;44 Suppl 1:109-16.
80. RT Franceschi, Xiao G. Osteoblasts: Staying the course. Meeting report from the 29th Annual Meeting of the American Society for Bone and Mineral Research. BoneKEy-Osteovision 4(12), 327-332.
81. Franceschi RT, Ge C, Xiao G, Roca H, Jiang D. Transcriptional regulation of osteoblasts. Ann N Y Acad Sci. 2007; 1116:196-207.
82. Chen D, Xiao G, Zhang M, Xing L, and Jonason JH. Post-translational regulation of Runx2 in bone cells. J Dent Res. 2008; 88(8): 693-703.
83. Franceschi RT, Ge C, Xiao G, Roca H, Jiang D. Transcriptional regulation of osteoblasts. Cells Tissues Organs. 2009;189(1-4):144-152.


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