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Wu Changfeng


Department of Biomedical Engineering


2005-2008 Ph. D. in Chemistry, Clemson University

2001-2004 Ph. D. in Physics, Changchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Sciences, China

1998-2001 M. S. in Material Science, Jilin University, China

1994-1998 B. S. in Material Science, Qilu University of Technology, China


Work Experience:

2016-now Professor of Biomedical Engineering, Southern University of Science and Technology

2012-2016 Professor of Biomedical Engineering College of Electronic Science and Engineering, Jilin University

2008-2012 Postdoctoral Fellow, Department of Chemistry, University of Washington

2004-2005 Postdoctoral Fellow, Department of Physics, Clemson University


Research Interests:

Multifunctional probes for biomedical diagnostics and therapeutics

Fluorescent semiconductor polymer dots for biological imaging and sensing

Single molecule techniques for biomolecular dynamics and cellular processes

Photophysics of semiconducting polymers and lanthanide materials

Design/construction of spectroscopic and imaging instrumentation


Honors and Awards:

2011 Thousand Young Talents, Recruitment Program of Global Experts by Chinese Government

2008 Outstanding Graduate Researcher Award, Department of Chemistry, Clemson University

2007 Departmental Research Incentive Award, Department of Chemistry, Clemson University

2003 Da-Heng Optical Research Award, Chinese Academy of Sciences   


Selected Publications:

1. Chang, K.; Liu, Z.; Fang, X.; Chen, H.; Men, X.; Yuan, Y.; Sun, K.; Zhang, X.; Yuan, Z.; Wu, C.*, Enhanced Phototherapy by Nanoparticle-Enzyme via Generation and Photolysis of Hydrogen Peroxide. Nano Lett. 2017, 17 (7), 4323-4329.
2. Chen, X.; Liu, Z.; Li R.; Shan, C.; Zeng, Z.; Xue, B.; Yuan, W.; Mo, P.; Xi, P.*; Wu, C.*; Sun, Y.*, Multicolor Super-resolution Fluorescence Microscopy with Blue and Carmine Small Photoblinking Polymer Dots. ACS Nano 2017, 11 (8), 8084-8091.
3. Chen, X.; Li R.; Liu, Z.; Sun, K.; Sun, Z.; Chen, D.; Xu, G.; Xi, P.; Wu, C.*; Sun, Y.*, Small Photoblinking Semiconductor Polymer Dots for Fluorescence Nanoscopy. Adv. Mater. 2017, 29 (5), 1604859.
4. Chen, D.; Wu, I. C.; Liu, Z.; Tang, Y.; Chen, H.; Yu, J.; Wu, C.*; Chiu, D. T.*, Semiconducting Polymer Dots with Bright Narrow-Band Emission at 800 nm for Biological Applications. Chem. Sci. 2017, 8 (5), 3390-3398.
5. Chen, H.; Zhang, J.; Chang, K.; Men, X.; Fang, X.; Zhou, L.; Li, D.; Gao, D.; Yin, S.; Zhang, X.; Yuan, Z.; Wu C.*; Biomaterials. 2017, 144, 42-52.
6. Chen, D.; Li, Q.; Meng, Z.; Guo, L.; Tang, Y.; Liu, Z.; Yin, S.; Qin, W.; Yuan, Z.; Zhang, X.; Wu. C.*, Bright Polymer Dots Tracking Stem Cell Engraftment and Migration to Injured Mouse Liver. Theranostics 2017, 7(7), 1820-1834.
7. Sun, K.; Tang, Y.; Li, Q.; Yin, S.; Qin, W.; Yu, J.; Chiu, D. T.; Liu, Y.; Yuan, Z.; Zhang, X.; Wu, C.*, In Vivo Dynamic Monitoring of Small Molecules with Implantable Polymer-Dot Transducer. ACS Nano 2016, 10 (7), 6769-6781.
8. Wu, C.; Chiu, D. T., Highly Fluorescent Semiconducting Polymer Dots for Biology and Medicine. Angew. Chem. Int. Ed. 2013, 52 (11), 3086-3109.
9. Yu, J.;‡ Wu, C.;‡ Zhang, X.; Ye, F.; Gallina, M. E.; Rong, Y.; Wu, I. C.; Sun, W.; Chan, Y. H.; Chiu, D. T., Stable Functionalization of Small Semiconducting Polymer Dots via Covalent Cross‐Linking and Their Application for Specific Cellular Imaging. Adv. Mater. 2012, 24 (26), 3498-3504.
10. Wu, C.; Hansen, S. J.; Hou, Q.; Yu, J.; Zeigler, M.; Jin, Y.; Burnham, D. R.; McNeill, J. D.; Olson, J. M.; Chiu, D. T., Design of Highly Emissive Polymer Dot Bioconjugates for in Vivo Tumor Targeting. Angew. Chem. Int. Ed. 2011, 50 (15), 3430-3434.
11. Wu, C.; Schneider, T.; Zeigler, M.; Yu, J.; Schiro, P. G.; Burnham, D. R.; McNeill, J. D.; Chiu, D. T., Bioconjugation of Ultrabright Semiconducting Polymer Dots for Specific Cellular Targeting. J. Am. Chem. Soc. 2010, 132 (43), 15410-15417.
12. Wu, C.; Jin, Y.; Schneider, T.; Burnham, D. R.; Smith, P. B.; Chiu, D. T., Ultrabright and Bioorthogonal Labeling of Cellular Targets Using Semiconducting Polymer Dots and Click Chemistry. Angew. Chem. Int. Ed. 2010, 49 (49), 9436-9440.
13. Wu, C.; Bull, B.; Christensen, K.; McNeill, J., Ratiometric Single‐Nanoparticle Oxygen Sensors for Biological Imaging. Angew. Chem. Int. Ed. 2009, 48 (15), 2741-2745.
14. Wu, C.; Bull, B.; Szymanski, C.; Christensen, K.; McNeill, J., Multicolor Conjugated Polymer Dots for Biological Fluorescence Imaging. ACS Nano 2008, 2 (11), 2415-2423.
15. Wu, C.; Szymanski, C.; Cain, Z.; McNeill, J., Conjugated Polymer Dots for Multiphoton Fluorescence Imaging. J. Am. Chem. Soc. 2007, 129 (43), 12904-12905.

Research Fields

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