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Lu Yi


Research Associate Professor

School of Medicine

0755-88015570

B-507

luy3@sustc.edu.cn

ACADEMIC
Yi Lu, PhD., a research associate professor at the Southern University of Science & Technology, School of Medicine, received her BS and MS degree in the Department of Biology from Nankai University, and a PhD in Immunology from the Tianjin Medical University. From 2002 to 2011, she served as a postdoctoral fellow and research scientist at the University of Michigan Medical School and the University of Pittsburgh Cancer Institute and Internal Medicine. Dr Lu is an active member of the American Association for Cancer Research (AACR) and the American Society for Bone and Mineral Research (ASBMR), a tenured Member of Chinese Society for Immunology. In 2011, as a key team member, she returned to China and set up the 1st Center for Translational Medicine in Southwest China.  Dr Lu became a professor and associate director of the Key Laboratory of Longevity and Aging-related Diseases, Ministry of Education, China & Center for Translational Medicine, Guangxi Medical University from 2011-2017. Her research interests have been focused on the study of tumor immuno-microenvironment and disseminated tumor cell dormancy.  She has been a recipient of numerous awards, including the best teacher award in medical school and AACR young investigator award.  She has great experience in teaching medical students.  The courses include Immunology, Molecular Biology, and Advanced Immunology.  Dr Lu is the author/co-author of over 70 peer-reviewed publications and a reviewer for Projects in National Science Foundation, China.
 
EDUCATION
1980-1984 Bachelor, Department of biology, Nankai University, heredity
1987-1990 Master, Institute of molecular biology, Nankai University, biochemistry and molecular biology
2004-2007 Doctor, Tianjin Medical University, immunology
 
EXPERIENCE
1984-1987 Assistant Researcher, family planning research institute, Tianjin Medical University
1990-2002 Lecturer/Associate professor, school of medical laboratory, Tianjin Medical University
2002-2003 Researcher, the University of Michigan Cancer Institute
2003-2010 Professor of Immunology, Tianjin Medical University
2004-2010 Researcher, department of pathology, school of medicine, University of Pittsburgh
2011-2016 Associate Director/Professor, the key laboratory of longevity and geriatric diseases, ministry of education, China, & the center for translational medicine, Guangxi Medical University
2015- Specially invited experts of nanning, Guangxi
2017- Research Associate Professor, school of medicine, Southern University of Science and Technology
 
RESEARCH INTERESTS
Tuomr microenvironment and cancer metastasis
Translational research on tumor early diagnosis biomarkers
Angiogenesis and tumor immune response
 
HONORS AND AWARDS
2009 - Scholar-in-Training Award, AACR
2007 - Young Investigator Travel Award, ASBMR
2005 - Scholar-in-Training Award, AACR
2003 - Second class of Tianjia Technology Progress Award, China
2003 - Third class of Tianjin Technology Progress Award, China
2000 - Third class of Tianjin Technology Progress Award, China
1997 - Third class of Tianjin Technology Progress Award, China
1994 - Third class of Xianyi Zhu Medical Award, China
 
BIBLIOGRAPHY
1. Junlin Shi, Lihui Wang, Chunlin Zou, Yudui Xia, Siyuan Qin, Evan Keller, Atsushi Mizokami, Jian Zhang*, Yi Lu*. Tumor microenvironment promotes prostate cancer cell dissemination via the Akt/mTOR pathway. Oncotarget, 2018, 9(10):9206-18.
2. Xia Y, Liu X, Zou C, Feng S, Guo H, Yang Y, Lei Y, Zhang J*, and Lu Y*. Garcinone C exerts antitumor activity by modulating the expression of ATR/Stat3/4E‑BP1 in nasopharyngeal carcinoma cells. Oncology Reports, 2018, 39:1485-93.
3. Jie Meng, Li-Hui Wang, Chun-Lin Zou, Sheng-Ming Dai, Jian Zhang*, Yi Lu*. C10orf116 Gene Copy Number Loss in Prostate Cancer: Clinicopathological Correlations and Prognostic Significance. Med Sci Monit 2017; 23:5176-5183.
4. Wenchu Wang, Lihui Wang, Atsushi Mizokami, Junlin Shi, Chunlin Zou, Jinlu Dai, Evan T. Keller, Yi Lu* and Jian Zhang*. Down-regulation of E-cadherin enhances prostate cancer chemoresistance via Notch signaling. Chinese Journal of Cancer, 2017; 36:35
5. Yong Lei, Yanhua Yi, Yang Liu, Xia Liu, Evan T. Keller, Chao-Nan Qian, Jian ZhangZ* and Lu Y*. Metformin targets multiple signaling pathways in cancer. Chinese Journal of Cancer, 2017, 36 (1):17.
6. Qiuyan Chen, Siyuan Qin, Yang Liu, Minghuang Hong, Chao-Nan Qian, Evan T Keller, Zhang J, Lu Y*. IGFBP-6 is a novel nasopharyngeal carcinoma prognostic biomarker. Oncotarget, 2016, Oct 18;7(42):68140-68150.
7. Jing Li, Xin Yang, Hao Guan, Atsushi Mizokami, Evan T. Keller, Xiaozhen Xu, Xia Liu, Jiyong Tan, Longyuan Hu, Lu Y*, Jian Zhang*. Exosome-derived microRNAs contribute to prostate cancer chemoresistance. International Journal of Oncology, 2016, 49:838-846.
8. Guihui Qin, Min Luo, Junze Chen, Yiwu Dang, Gang Chen, Li Li, Jing Zeng, Lu Y, Jie Yang. Reciprocal activation between MMP-8 and TGF-β1 stimulates EMT and malignant progression of hepatocellular carcinoma. Cancer Letters, 2016 Apr 28;374(1):85-95.
9. Yu Zhu, Chunlin Zou, Zhe Zhang, Chaonan Qian, Xin Yang, Junlin Shi, Yudui Xi, Zhang J*, Lu Y*. MEK inhibitor diminishes nasopharyngeal carcinoma (NPC) cell growth and NPC-induced osteoclastogenesis via modulating CCL2 and CXCL16 expression. Tumor Biology, 2015, 36(11):8811-8.
10. Lu Y, Gu X, Chen L, Yao Z, Song J, Niu X, Xiang R, Cheng T, Qin Z, Deng W, Li LY. Interferon-γ produced by tumor-infiltrating NK cells and CD4+ T cells downregulates TNFSF15 expression in vascular endothelial cells. Angiogenesis. 2014 Jul;17(3):529-40.
11. Lu Y, Zhang Z, Yan Z, Chen L, Deng W, Lotze M, Wang Z, Lin X, Li LY.  Restoration of p53 Functions in Breast Cancer Cells in vivo with Recombinant GnRH-p53 Fusion Protein Enhances 5-Fluorouracil Anticancer Efficacy.  Apoptosis, Oct;18(10):1214-23,2013.
12. Zhang J, Lu Y, and Pienta KJ. Multiple roles of CC chemokine ligand 2 (CCL2) in promoting prostate cancer growth. J National Cancer Institute 102(8):522-8, 2010.
13. Lu Y*, Chen Q, Corey E, Xie W, Fan J, Mizokami A, and Zhang J. Activation of MCP-1/CCR2 axis promotes prostate cancer growth in bone. Clin Exp Metastasis 26(2):161-9, 2009.
14. Lu Y, Nie DB, Witt WT, Chen Q, Shen M, Xie H, Lai L, Dai Y, Zhang J.  Expression of fat-1 gene diminishes prostate cancer growth in vivo through enhancing apoptosis and inhibiting GSK-3β phosphorylation. Molecular Cancer Therapeutics 7(10):3203-11, 2008.
15. Lu Y, Wang J, Xu Y, Koch AE., Cai Z, Chen X, Galson DL, Taichman RS, and Zhang J. CXCL16 functions as a novel chemotactic factor for prostate cancer cells in vitro. Mol Cancer Res 6(4): 546-54, 2008.
16. Lu Y, Cai Z, Xiao G, Keller ET, Mizokami A, Yao Z, Roodman GD, Zhang J.  Monocyte chemotactic protein-1 mediates prostate cancer-induced bone resorption. Cancer Res 67:3646-53, 2007.
17. Lu Y, Cai Z, Galson DL, Xiao G, Liu YL, George D, Melhem MF, Yao Z and Zhang J. Monocyte chemotactic protein-1 (MCP-1) acts as a paracrine and autocrine factor for PCa growth and invasion. Prostate 66:1311-8, 2006.
18. Zhang J# Dai J, Lu Y# (Co-first author), Yao Z, O’Brein C, Qi W, Hall D, Ershler WB, Keller ET. In vivo visualization of aging-associated gene transcription: evidence for free radical theory of aging. Experimental Gerontology 39:239-247, 2004.
 

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