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Faculty

Hu Yuhui


Associate Professor

Department of Biology

huyh@sustc.edu.cn

Self-introduction:
Dr. Yuhui Hu has a long-standing interest and experience in Functional Genomics, Chemical Biology, and Chinese Medicine (CM). She has particular interest in combining her expertise in both systems biology (genomics, metabolomics, proteomics) and CM theories for the research-driven development of new drugs that are originated from CM natural compounds. She has for the first time established a series of high-throughput platforms, such as Connectivity Map of TCM and Transfected Cell Microarrays, for studying the functional mechanism of CM systematically, and in the meantime allowing for efficient assessment of therapeutic efficacies of CM-derived new drug candidates. The research achievement includes, for example, the first report on the genome-wide gene regulatory effects of Ginsenosides. She has identified a few CM-originated compounds with potent anti-cancer and neural protection effects, and is currently applying these into targeted cancer therapy (Precision Medicine).

 

Professional Experience:
◆ 08/2016 – present      Associate Professor, Department of Biology, Southern University of Science and Technology, Shenzhen, China
◆ 02/2009 – 08/2016     Senior research scientist, The Berlin Institute for Medical Systems Biology (BIMSB),  Max Delbrück Center for Molecular Medicine (MDC), Berlin, Germany
◆ 05/2007 – 01/2009     Research Group Leader (independent PI)—Pharmacogenomics & Chemical Genetics group. Department of Vertebrate Genomics, Max-Planck-Institute for Molecular Genetics, Berlin, Germany        
◆ 06/2006 – 04/2007     Post-doc Fellow, Department of Vertebrate Genomics, Max-Planck-Institute for Molecular Genetics, Berlin, Germany
◆ 10/2002 - 06/2006      Ph.D., Department of Vertebrate Genomics, Max-Planck-Institute for Molecular Genetics, Berlin, Germany
◆ 01/2002 - 10/2002      Visiting Research Scholar, School of Chinese Medicine & Department of Biology, Hong Kong Baptist University, Hong Kong, China.
◆  07/1994 - 01/2002     Research Assistant, Lecturer(since 1999), School of Pharmacy, West China University of Medical Sciences (WCUMS) (joint to Sichuan University in 2001), Chengdu, China


Educational Background:
◆ 10/2002 - 06/2006    Ph.D. in Functional Genomics, Max-Planck-Institute for Molecular Genetics (MPIMG), Berlin, Germany.    Supervisor: Hans Lehrach
◆ 09/1998 - 07/2001    M.Sc. in Pharmacy/Pharmacognosy, School of Pharmacy, West China University of Medical Sciences (WCUMS) (joint to Sichuan University in 2001), Chengdu, China.
◆ 09/1990 - 07/1994    B.Sc. in Chinese Materia Medica (CMM), Department of CMM, Chengdu University of Traditional Chinese Medicine (CDUTCM), Chengdu, China
 
Selected Publication:
Wang, Y., Gogol-Döring, A., Hu, H., Fröhler, S., Ma, Y., Jens, M., Maaskola, J., Murakawa, Y., Quedenau, C., Landthaler, M., Kalscheuer, V., Wieczorek, D., Wang, Y., Hu, Y. * and Chen, W. *: Integrative analysis revealed the molecular mechanism underlying RBM10-mediated splicing regulation. EMBO Mol Med. 2013 Sep;5(9):1431-42. (* Shared corresponding author)
Mazin P, Xiong J, Liu X, Yan Z, Zhang X, Li M, He L, Somel M, Yuan Y, Phoebe Chen YP, Li N, Hu Y, Fu N, Ning Z, Zeng R, Yang H, Chen W*, Gelfand M*, Khaitovich P*.(2013) Widespread splicing changes in human brain development and aging. Mol Syst Biol. 2013; 9:633.
Li N, You X, Chen T, Mackowiak SD, Friedländer MR, Weigt M, Du H, Gogol-Döring A, Chang Z, Dieterich C, Hu Y, Chen W (2013) Global profiling of miRNAs and the hairpin precursors: insights into miRNA processing and novel miRNA discovery. Nucleic Acids Res. 2013 Apr 1;41(6):3619-34
Thu-Hang Pham, Christopher Benner, Monika Lichtinger, Lucia Schwarzfischer, Yuhui Hu, Reinhard Andreesen, Wei Chen and Michael Rehli: Dynamic epigenetic enhancer signatures reveal key transcription factors associated with monocytic differentiation states.  Blood 2012 Jun 14;119(24):e161-71.
Liu X, Somel M, Tang L, Yan Z, Jiang X, Guo S, Yuan Y, He L, Oleksiak A, Zhang Y, Li N, Hu Y, Chen W, Qiu Z, Pääbo S, Khaitovich P: Extension of cortical synaptic development distinguishes humans from chimpanzees and macaques. Genome Res. 2012 Apr;22(4):611-22. 
Somel M, Liu X, Tang L, Yan Z, Hu H, Guo S, Jiang X, Zhang X, Xu G, Xie G, Li N, Hu Y, Chen W, Pääbo S, Khaitovich P. MicroRNA-Driven Developmental Remodeling in the Brain Distinguishes Humans from Other Primates. PLoS Biol. 2011 Dec;9(12):e1001214.
Zheng Yan, Hai Yang Hu, Xi Jiang, Vera Maierhofer, Elena Neb, Liu He, Yuhui Hu, Hao Hu, Na Li, Wei Chen, and Philipp Khaitovich. Widespread expression of piRNA-like molecules in somatic tissues. Nucleic Acids Res. 2011 Aug;39(15):6596-607.)
Yuhui Hu and Michal Janitz. High-throughput subcellular protein localization using transfected-cell arrays. Subcellular protein localization using cell arrays. Methods Mol Biol. 2011;706:53-72. 
Mehmet Somel, Song Guo, Ning Fu, Zheng Yan, Hai Yang Hu, Ying Xu, Yuan Yuan, Zhibin Ning, Yuhui Hu, Corinna Menzel, Hao Hu, Michael Lachmann, Rong Zeng, Wei Chen, and Philipp Khaitovich. MicroRNA, mRNA, and protein expression link development and aging in human and macaque brain. Genome Research 2010; 20:1207-1218
Weimin Qiu, Yuhui Hu, Tom E. Andersen, Abbas Jafari, Na Li, Wei Chen, and Moustapha Kassem. Tumor necrosis factor receptor superfamily member 19 (TNFRSF19) regulates differentiation fate of human mesenchymal (stromal) stem cells through canonical WNT signaling and C/EBP. J Biol Chem. 2010; 7;285(19):14438-49.
Yuhui Hu, Hans Lehrach and Michal Janitz, Apoptosis screening of human chromosome 21 proteins reveals novel cell death regulators. Molecular Biology Reports 2010; 37(7): 3381–3387.
Chen W, Ullmann R, Langnick C, Menzel C, Wotschofsky Z, Hu H, Döring A, Hu Y, Kang H, Tzschach A, Hoeltzenbein M, Neitzel H, Markus S,Wiedersberg E, Kistner G, van Ravenswaaij-Arts CM, Kleefstra T, Kalscheuer VM, Ropers HH. Breakpoint analysis of balanced chromosome rearrangements by next-generation paired-end sequencing. Eur J Hum Genet. 2010 May;18(5):539-43.
Yuhui Hu, Hans Lehrach and Michal Janitz, Comparative analysis of an experimental subcellular protein localization assay and in silico prediction methods. Journal of Molecular Histology 2009 Oct;40(5-6):343-52.
Fiebitz A, Nyarsik L, Haendler B, Hu YH, Wagner F, Thamm S, Lehrach H, Janitz M, Vanhecke D, High-throughput mammalian two-hybrid screening for protein-protein interactions using transfected cell arrays,BMC Genomics 2008, 9:68
Y.H. Hu, H. J. Warnatz, D. Vanhecke, F. Wagner, A. Fiebitz, S. Thamm, P. Kahlem, H. Lehrach, M. L. Yaspo, and M. Janitz, Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins, BMC Genomics 2006, 7:155.
Y.H. Hu, D. Vanhecke, M. Janitz, High-throughput subcellular protein localization using cell arrays, Biochemical Society Transaction 2005 Dec;33(Pt 6):1407-8
L. Liu, …Y. H. Hu, R. N. S. Wong, Effects of Si-Jun-Zi decoction polysaccharides on cell migration and gene expression in wounded rat intestinal epithelial cells, British Journal of Nutrition (2005) 93, 21–29.    
Hu Yuhui, ZHANG Hao, Zhang Zhi-Feng, Determine total flavonoids and scutellarin of Erigeron genus. Chin. J. Pharm. Anal. (2005) 25(1).
 
Open Positions:
◆ We are currently recruiting highly-motivated lab members including Postdocs, Research Assistants, PhD & Master students, Interns.
To apply, send an email, with you CV, a brief outline of your research experience & interests, motivation and mid-term career goals, and for Postdoc & PhD students, contact details of 2 referees, to huyh (AT)sustc.edu.cn

 

 

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