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Ho Chun Loong


Assistant Professor

Department of Biomedical Engineering

hejl@sustc.edu.cn

Dr Ho Chun Loong is a Malaysian-born Assistant Professor under the Department of Biomedical Engineering at the Southern University of Science and Technology (SUSTech). His research focuses primarily on using synthetic biology and protein engineering to address various health and environmental issues. This includes establishing a platform where researchers could share their constructs and systematically amass these genetic constructs for protein engineering purposes.

In 2013,he acquired his Doctorate in Biochemistry from the Nanyang Technological University of Singapore under the Liang Zhao-xun laboratory, where he studied the enzymatic production of secondary metabolites produced from the multi-modular polyketide synthase and on engineering proteins to function as biosensors to track the intrinsic levels of bacterial intracellular signalling molecules, cyclic di-GMP. He then did his postdoctoral fellowship under the Synthetic Biology for Clinical and Technological Innovations centre (SynCTI) in the National University of Singapore, where he engineers proteins to function as tools that confer therapeutic property to probiotic cells and commensal microbes.
He published various articles including in Nature Biomedical Engineering, Journal of American Chemistry Society, and ACS Synthetic Biology, with over 150 citations. He has filed two patents to date.

 

Education background:
2003 – 2006 School of Science and Technology, Universiti Malaysia Sabah, Malaysia. Bachelor of Science (Hons)
2008 – 2013 School of Biological Sciences, Nanyang Technological University, Singapore. Ph. D. in Biochemistry

 

Work experience:
2018 – Present Assistant Professor, Department of Biomedical Engineering, Southern University of Science and Technology, China.
2014 – 2018 Research Fellow and Cluster Leader of Therapeutic Research, Synthetic Biology for Clinical and Technological University, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
2013 – 2013 Project Officer, School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore.
2012 – 2013 Project Officer, School of Biological Science, Nanyang Technological University, Singapore.

 

Honours and Rewards:
2008 NTU Research Scholarship (for PhD)

 

Representative Papers:
1. Ho CL, Tan HQ, Chua KJ, Kang A, Lim KH, Ling KL, Yew WS, Thiery JP, Chang MW. Engineered commensal microbes for diet-mediated colorectal-cancer chemoprevention. Nature Biomedical Engineering, 2018, 2, 27-37
2. Lubkowicz D*, Ho CL*, Lee YS, Chang MW. Reprogramming probiotic Lactobacillus reuteri as a biosensor for detecting Staphylococcal quorum sensing. ACS Synthetic Biology., 2018 DOI: 10.1021/acssynbio.8b00063 (* all authors contributed equally)
3. Hoang LP*, Ho CL*, Wong Adison*, Lee YS, Chang MW. Applying the design-build-test paradigm in microbiome engineering. Current Opinion in Biotechnology, 2017, 48, 85-93 (* all authors contributed equally)
4. Ho CL, Hwang IY, Loh K, Chang MW. Matrix-immobilized yeast for large-scale production of recombinant human lactoferrin. MedChemComm, 2015, 6, 486-491
5. Ho CL, Chong KSJ, Akosua JO, Chuah MLC, Tan SM, Liang ZX. Visualizing the Perturbation of Cellular Cyclic di-GMP Levels in Bacterial Cells. Journal of the American Chemical Society, 2013, 135 (2), pp 566–569
6. Ho CL, Koh SL, Chuah MLC, Luo Z, Tan WJ, Low DKS, Liang ZX. Rational Design of Fluorescent Biosensor for cyclic di-GMP. Chembiochem: a European journal of chemical biology., 2011, 12(18):2753-8
7. Hwang IY, Tan MH, Koh E, Ho CL, Poh CL, Chang MW. Reprogramming Microbes to Be Pathogen-Seeking Killers. ACS Synthetic Biology., 2013, DOI: 10.1021/sb400077j
8. Rasouliha BH, Ling H, Ho CL, Chang MW. A predicted immunity protein confers resistance to pyocin S5 in a sensitive strain of Pseudomonas aeruginosa. Chembiochem: a European journal of chemical biology., 2013, DOI: 10.1002/cbic.201300410
9. Sun H, Ho CL, Ding F, Soehano I, Liu XW, Liang ZX. Synthesis of (R)-Mellein by a Partially Reducing Iterative Polyketide Synthase. Journal of the American Chemical Society. 2012; 134(29):11924-7.
10. Qi Y, Xu LH, Dong XM, Yau YH, Ho CL,  Koh SL, Shochat SG,  Chou SH, Tang K, Liang ZX.  Functional Divergence of FimX in PilZ binding and Type IV Pili Regulation. Journal of bacteriology. 2012
11. Lim J, Kong R, Murugan E, Ho CL, Liang ZX. Solution Structures of the Acyl Carrier Protein Domain from the Highly Reducing Type I Iterative Polyketide Synthase CalE8. PloS one. 6(6):e20549.

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