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Guo Hongwei

Chair Professor

Department of Biology



Dr. Hongwei Guo is a “Changjiang Scholars Program” distinguished professor and a chair professor at SUSTC. He is also the director of the newly established

Institute of Nutrition and Food Safety (INFS).  Dr. Hongwei Guo has devoted himself and his lab to the research field of plant molecular biology and genetics for 

decades. Particularly, his group had made great contributions to the understanding of plant ethylene signaling mechanisms. They have originally established the

protein degradation model and the RNA decay model for ethylene action, and revealed the crosstalk mechanisms between ethylene and other phytohomones

(auxin, JA, and GA) and environmental factors (light, salt, and other stresses). Significant discoveries and findings from Guo’s lab were published in top peer-reviewed journals such as Cell, Nature, Science, PNAS, Plant Cell, Current Biology, among others. Consistent with his great scientific achievements and 

reputation, Dr. Guo also serves as standing committee member of AllChina Youth Federation, director of the youth work committee of Botanical Society of 

China, standing director of Botanical Society of China and Crop Science Society of China, reviewer of National Natural Science Foundation of China, and 

editorial board member of Mol Plant, PCP, JIPB and JGG.


Professional Experience:
◆2016 - present, Chair Professor, Department of Biology, SUSTC.
◆2005 - 2015, Professor, School of Life Sciences, PKU.
◆2001-2005, Postdoc, Salk Institute, USA.
Educational Background:
◆1996-2001, Ph.D., Cell and Developmental Biology, Department of Molecular, Cell and Development Biology, University of California, Los Angeles.
◆1992-1995, M.S., Department of Biotechnology, School of Life Sciences, Peking University.
◆1988-1992, B.S., Department of Biology, Nankai University. 
Honors & Awards:
◆2014 Tan Jiazhen Life Science Innovation Award.
◆2013 Person of the Year (2012) by Scientific Chinese, China Association for Sciences and Technology.
◆2011 China Young Scientist Award, China Association for Sciences and Technology.
◆2009 China Excellent Youth Award (13th May-Fourth Medal).
◆2008 Outstanding Young Investigatorship, Chinese Society of Botany.
◆2007 Beijing Excellent Youth Award (22nd May-Fourth Medal).
◆2006 National Outstanding Young Investigator Award, NSF of China.
◆2006“Changjiang Scholar” Distinguished Professorship, Ministry of Education.
Selected Publication: 
1.Li W., Ma M., Feng Y., Li H., Wang Y., Ma Y., Li M., An F., and Guo H.* (2015). EIN2-directed translational regulation of ethylene signaling in Arabidopsis. Cell, 163: 670-683.
2.Zhang X., Zhu Y., Liu X., Hong X., Xu Y., Zhu P., Shen Y., Wu H., Ji Y., Wen X., Zhang C., Zhao Q., Wang Y., Lu J. and Guo H.* (2015). Suppression of endogenous gene silencing by bidirectional cytoplasmic RNA decay in Arabidopsis. Science, 348: 120-123.
1.Peng J., Li Z., Wen X., Li W., Shi H., Yang L., Zhu H. and Guo H.* (2014). Salt-Induced Stabilization of EIN3/EIL1 Confers Salinity Tolerance by Diminishing ROS Accumulation in Arabidopsis. PLoS Genetics, 10:e1004664
2.Zhang X., Zhu Z., An F., Hao D., Li P., Song J., Yin C., and Guo H.* (2014) Jasmonate-Activated MYC2 Represses ETHYLENE INSENSITIVE3 activity to antagonize ethylene-promoted apical hook formation in Arabidopsis. Plant Cell 26:1105-17.
3.Zhong S., Shi H., Xue C., Wei N., Guo H.* and Deng X.* (2014) An ethylene-orchestrated circuitry coordinates a seedling's response to soil cover and etiolated growth. Proc. Natl. Acad. Sci. U S A, 111:3913-20. ( *Co-Corresponding)
4.Li Z., Zhao Y., Liu X., Peng J., Guo H.*, and Luo J.* (2014). LSD 2.0: an update of the leaf senescence database. Nucleic Acids Research, 42:D12000-5. ( *Co-Corresponding)
1.Li Z., Peng J., Wen X. and Guo H.* (2013).  ETHYLENE-INSENSITIVE3 is a senescence-associated  gene  that  accelerates  age-dependent  leaf  senescence  by directly repressing miR164 transcription in Arabidopsis. Plant Cell 25:3311-28
2.Zhang X, Chen Y, Lin X, Hong X, Zhu Y, Li W, He W, An F, Guo H.* (2013) Adenine Phosphoribosyl Transferase 1 is a key enzyme catalyzing cytokinin conversion from nucleobases to nucleotides in Arabidopsis. Mol Plant. 6:1661-72
3.Song S, Qi T, Fan M, Zhang X, Gao H, Huang H, Wu D, Guo H, Xie D. (2013) The bHLH Subgroup IIId Factors Negatively Regulate Jasmonate-Mediated Plant Defense and Development. PLoS Genet. Jul;9(7):e1003653.
4.Ji Y and Guo H.* (2013). From endoplasmic reticulum (ER) to nucleus: EIN2 bridges the gap in ethylene signaling. Mol Plant. 6:11-4.
5.Zheng D, Han X, An Y, Guo H, Xia X, Yin W. (2013). The nitrate transporter NRT2.1 functions in the ethylene response to nitrate deficiency in Arabidopsis. Plant Cell Environ. Jan 11. doi: 10.1111/pce.12062.
6.Li H, Xu T, Lin D, Wen M, Xie M, Duclercq J, Bielach A, Kim J, Reddy GV, Zuo J, Benková E, Friml J, Guo H, Yang Z.(2013). Cytokinin signaling regulates pavement cell morphogenesis in Arabidopsis. Cell Res. 23:290-9.
7.Kim H., Kwon S., Jang Y., Nam M., Chung J., Na Y., Guo H. and Park O. (2013). GDSL LIPASE1 modulates plant immunity through feedback regulation of ethylene signaling. Plant Phys. 163:1776-91.
1.Wen X, Zhang C, Ji Y, Zhao Q, He W, An F, Jiang L, Guo H.* (2012). Activation of ethylene signaling is mediated by nuclear translocation of the cleaved EIN2 carboxyl terminus. Cell Res. 22:1613-6.
2.Wang Q, Fristedt R, Yu X, Chen Z, Liu H, Lee Y, Guo H, Merchant SS, Lin C. (2012). The γ-carbonic anhydrase subcomplex of mitochondrial complex I is essential for development and important for photomorphogenesis of Arabidopsis. Plant Physiology 160:1373-83.
3.Zhong S., Shi H., Xue C., Wang L., Xi Y., Li J., Quail P.H., Deng X.*, and Guo H.* (2012). A Molecular Framework of Light-Controlled Phytohormone Action in Arabidopsis. Current Biology 22: 1530-35
4.Men Y., Yu Q., Chen Z., Wang J., Huang Y.* and Guo H.* (2012). A high-throughput imaging system to quantitatively analyze the growth dynamics of plant seedlings. Integrative Biology 4:945-52.
5.Shi Y., Tian S., Hou L., Huang X., Zhang X., Guo H. and Yang S. (2012). Ethylene signaling negatively regulates freezing tolerance by repressing expression of CBF and Type-A ARR genes in Arabidopsis. Plant Cell 24:2578-95.
6.Li Z, Peng J, Wen X, Guo H.* (2012). Gene Network Analysis and Functional Studies of Senescence-associated Genes Reveal Novel Regulators of Arabidopsis Leaf Senescence. J Integr Plant Biol. 54:526-39.
7.An F., Zhu Z., Zhang X., Ji Y., He W., Jiang Z., Li M., and Guo H.* (2012). Coordinated regulation of apical hook development by gibberellin and ethylene in etiolated Arabidopsis seedlings. Cell Res. 22: 915-27.
1.He W., Brumos J., Li H., Ji Y., Ke M., Gong X., Zeng Q., Li W., Zhang X., An F., Wen X., Li P., Chu J., Sun X., Yan C., Yan N., Xie D., Raikhel N., Yang Z., Stepanova A.N., Alonso J.M. and Guo H.* (2011). A small-molecule screen identifies L-Kynurenine as a competitive inhibitor of TAA1/TAR activity in ethylene-directed auxin biosynthesis and root growth in Arabidopsis. Plant Cell 23:3944-60
2.Stepanova A.N., Yun J., Robles L.M., Novak O., He W., Guo H., Ljung K., Alonso J.M. (2011). The Arabidopsis YUCCA1 flavin monooxygenase functions in the Indole-3-Pyruvic Acid branch of auxin biosynthesis. Plant Cell 23:3961-73
3.Zhu Z., An F., Feng Y., Li P., Xue L., A M., Jiang Z., Kim J., To T., Li W., Yu Q., Dong Z., Chen W., Seki M., Zhou J. and Guo H.* (2011). Derepression of ethylene-stabilized transcription factors (EIN3/EIL1) mediates jasmonate and ethylene signaling synergy in Arabidopsis . Proc. Natl. Acad. Sci. USA. 108:12539-44.
4.Zhao Q. and Guo H.* (2011). Paradigms and paradox in the ethylene signaling pathway and interaction network. Mol. Plant 4:626-34
5.Li H., Lin D., Dhonukshe P., Nagawa S., Chen D., Friml J., Scheres B., Guo H., Yang Z. (2011). Phosphorylation switch modulates the interdigitated pattern of PIN1 localization and cell expansion in Arabidopsis leaf epidermis. Cell Res. 21:970-8
6.Jiang Z, Liu X, Peng Z, Wan Y, Ji Y, He W, Wan W, Luo J,* Guo H.* (2011). AHD2.0: an update version of Arabidopsis Hormone Database for plant systematic studies. Nucleic Acids Research 39: D1123-9. ( *Co-Corresponding Author)
7.Liu X., Li Z. Jiang Z., ZhaoY., Peng J., Jin J., Guo H*., Luo J.* (2011). LSD: a leaf senescence database. Nucleic Acids Research 39: D1103-7. ( *Co-Corresponding Author)
1.  An F., Zhao Q., Ji Y., Jiang Z., Yu X., Liu Y., Han Y., Zhang C., Zhang S., Ecker J.R., and Guo H.* (2010). Ethylene-Induced Stabilization of ETHYLENE INSENSITIVE3 and EIN3-LIKE1 Is Mediated by Proteasomal Degradation of EIN3 Binding F-Box 1 and 2 That Requires EIN2 in Arabidopsis . Plant Cell 22:2384-401
2.Jiang Z. and Guo H.* (2010). A comparative genomic analysis of plant hormone related genes in different species. J. Genet. Genomics 37:219-30
3.Zhong S., Shi H., Xi Y. and Guo H.* (2010). Ethylene is crucial for cotyledon greening and seedling survival during de-etiolation. Plant Signaling & Behavior 5: 739-42
1.Zhong S., Zhao M., Shi T., Shi H., An F., Zhao Q. and Guo H.* (2009). EIN3/EIL1 cooperate with PIF1 to prevent photo-oxidation and to promote greening of Arabidopsis seedlings. Proc. Natl. Acad. Sci. USA. 106: 21431-36.
2.Peng Z., Zhou X., Li L., Yu X., Li H., Jiang Z., Cao G., Bai M., Wang X., Jiang C., Lu H., Hou X., Qu L.,Wang Z., Zuo J., Fu X., Su Z., Li S., and Guo H.* (2009). Arabidopsis Hormone Database: a comprehensive genetic and phenotypic information database for plant hormone research in Arabidopsis. Nucleic Acids Research 37: 975-82.
3.Chen H., Xue L., Chintamanani S., Germain H., Lin H., Cui H., Cai R., Zuo J., Tang X., Li X., Guo H., and Zhou J. (2009). ETHYLENE INSENSITIVE3 and ETHYLENE INSENSITIVE3-LIKE1 repress SALICYLIC ACID INDUCTION DEFICIENT2 expression to negatively regulate plant innate immunity in Arabidopsis. Plant Cell 21:2527-40.
4.Li H., Wong W., Zhu L., Guo H., Ecker J.R., and Li N. (2009). Phosphoproteomic analysis of ethylene-regulated protein phosphorylation in etiolated seedlings of Arabidopsis mutant ein2 using two-dimensional separations coupled with a hybrid quadruple time-of-flight mass spectrometer. Proteomics 9:1646-61.
1. Zhu Z. and Guo H.* (2008). Genetic basis of ethylene perception and signal transduction in Arabidopsis. Journal of Integrative Plant Biology 50: 808-15.
1. Li H. and Guo H.* (2007). Molecular basis of the ethylene signaling and response pathway in Arabidopsis. Journal of Plant Growth Regulation 26: 106-17.
1.Olmedo G., Guo H., Gregory B., Nourizadeh S., Aguilar-Henonin L., Li H., An F., Guzman P., and Ecker J.R. (2006). ETHYLENE-INSENSITIVE5 encodes a 5'→3' exoribonuclease required for posttranscriptional regulation of the EIN3-targeting F-box proteins EBF1/2. Proc. Natl. Acad. Sci. USA. 103: 13286-93 (* co-first author).
2.An F., and Guo H.* (2006) The Molecular Mechanism of Ethylene Signal Transduction.Chinese Botany Bulletin 23: 531-42.
Before 2005: 
1.Guo H. and Ecker J.R. (2004). The ethylene signaling pathway: new insights. Curr Opin Plant Biol. 7: 40-9.
2.Guo H. and Ecker J.R. (2003). Plant responses to ethylene gas are mediated by SCFEBF1/EBF2-dependent proteolysis of EIN3 transcription factor. Cell 115: 667-77.
3.Shalitin D., Yang H., Mockler T., Maymon M., Guo H., Whitelam G., and Lin C. (2002). Regulation of Arabidopsis cryptochrome 2 by blue light-dependent phosphorylation. Nature 417: 763-7.
4.Guo H., Mockler T., Duong H., and Lin C. (2001). SUB1, an Arabidopsis Ca2+-binding protein involved in cryptochrome and phytochrome coaction. Science 291: 487-90.
5.Guo H., Duong H., Ma N., and Lin C. (1999). The Arabidopsis blue light receptor cryptochrome 2 is a nuclear protein regulated by a blue light-dependent post-transcriptional mechanism. Plant J. 19: 279-87.
6.Mockler T., Guo H., Yang H., Duong H., and Lin C. (1999). Antagonistic actions of the Arabidopsis cryptochromes and phytochrome B in the regulation of floral induction. Development 126: 2073-82.
7.Guo H., Yang H., Mockler T., and Lin C. (1998). Regulation of flowering time by Arabidopsis photoreceptors. Science 279: 1360-3.
8.Lin  C.,  Yang  H.,  Guo  H.,  Mockler  T.,  Chen  T.,  and  Cashmore  A.R.  (1998). Enhancement of blue-light sensitivity of Arabidopsis seedling by a blue light receptor cryptochrome 2. Proc. Natl. Acad. Sci. USA 95: 2686-90.


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