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Faculty

Deng Yi


Associate Professor

Department of Biology

0755-88018085

Room 236 ,Faculty Research Building No. 1

dengy@sustc.edu.cn

Research Interests:

◆Microenvironment, signal transduction and diseases: Cells interact with extra cellular matrix through the forming cell-matrix adhesions, which in turn leads to reorganization of actin cytoskeleton and signal transduction. The assembly and disassembly of cell-matrix adhesions allow cells to move and are critical for embryonic organ development and postnatal cell function and tissue homeostasis. Conversely, defective control of cell-matrix formation is involved in cancer metastasis. The goal of our research is to obtain a detailed understanding of the molecular mechanisms by which the cell-matrix adhesion is regulated. We combine cell biology and biochemical approaches to investigate cell-adhesion dynamics. Recent interests include the mechanism of assembly, disassembly, and trafficking of adhesion protein complexes that act in regulation of integrin functions. Two protein complexes that emerged from these studies are ILK-PINCH-parvin ternary complex and kindlin-migfilin-filamin complex. ILK-PINCH-parvin complex functions as a signal hub of integrin-mediated signaling by interacting with actin cytoskeleton and many diverse signalling pathways, while kindlin-migfilin-filamin complex play key roles in integrin activation. We use microscopy, including cutting edge fluorescence-based technologies to study questions at different spatial scales.

◆Pancreatic beta-cell biology: The molecular mechanism by which Binding immunoglobulin protein (Bip)acts in protecting human islet amyloid polypeptide (hIAPP) induced beta-cell damage.

 

Professional Experience:

◆ 2011-2012 Research Associate The Chinese University of Hong Kong

◆ 2009-2011 Research Associate The University of Science and Technology of Hong Kong

◆ 2003-2008 Postdoctoral Fellow National Institutes of Health (NIH, USA)

 

Educational Background:

◆ PhD    Department of Biology    Ruhr-University Bochum (Germany)    2002

◆ MS     Department of Biology    Shandong University                 1999

◆ BS      Department of Biology    Shandong University                 1996

 

Selected Publication:

Shi W, Xu G, Wang C, Sperber SM, Chen Y, Zhou Q, Deng Y*, Zhao H*. Heat Shock 70-kDa Protein 5 (Hspa5) Is Essential for Pronephros Formation by Mediating Retinoic Acid Signaling.J Biol Chem. (2015) 290:577. (* co-corresponding author)
Lei Y, Guo X, Deng Y, Chen Y, Zhao H Generation of gene disruptions by transcription activator-like effector nucleases (TALENs) in Xenopus tropicalis embryos. Cell Biosci. (2013) 3: 21.
Kang ZF, Deng Y, Zhou Y, Fan RR, Chan JC, Laybutt DR, Luzuriaga J, Xu G. Pharmacological reduction of NEFA restores the efficacy of incretin-based therapies through GLP-1 receptor signalling in the beta cell in mouse models of diabetes. Diabetologia(2013) 56: 423.
Lei Y, Guo X, Liu Y, Cao Y, Deng Y, Chen X, Cheng CH, Dawid IB, Chen Y, Zhao H. Efficient targeted gene disruption in Xenopus embryos using engineered transcription activator-like effector nucleases (TALENs). Proc Natl Acad Sci U S A. (2012) 109: 17484.
Kam RK, Deng, Y, Chen Y, Zhao H. Retinoic acid synthesis and functions in early embryonic development.Cell Biosci. (2012) 2: 11.
Deng Y, Guo Y, Watson H, Au WC, Shakoury-Elizeh M, Basrai MA, Bonifacino JS, Philpott CC. GGA2 mediates sequential ubiquitin-independent and -dependent steps in the trafficking of ARN1 from the trans-golgi network to the vacuole. J Biol Chem (2009) 284: 23830-23841.
Deng Y, Golinelli-Cohen M, Smirnova E, and Jackson CL. A COPI coat subunit interacts directly with an early-Golgi localized Arf Exchange Factor. EMBO Rep (2009) 10: 58-64.

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